gnao1a guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gnao1aprovided by ZNC
Official Full Name: guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1757
See related: Ensembl:ENSDARG00000016676 AllianceGenome:ZFIN:ZDB-GENE-040426-1757
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gnao1; zgc:73315; wu:fq26h05
Summary: Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and dopamine receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Is expressed in gill; nervous system; neural rod; and trigeminal placode. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Orthologous to human GNAO1 (G protein subunit alpha o1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (22793161..22976664)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (22804071..22987598)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb78f11.y1 (e-PCR)
- UniSTS:191444

fk55g03.x1 (e-PCR)
- UniSTS:201189

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables corticotropin-releasing hormone receptor 1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info
enables mu-type opioid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a; guanine nucleotide-binding protein G(o) subunit alpha

Names: Galpha o1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200787.2 → NP_957081.1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a

See identical proteins and their annotated locations for NP_957081.1

Status: VALIDATED

Source sequence(s)

BX001001, BX088710, BX663522

UniProtKB/TrEMBL

A0A8M1PFR7, Q6PBP1

Related

ENSDARP00000124476.1, ENSDART00000149685.3

Conserved Domains (1) summary

cd00066
Location:34 → 348

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

22793161..22976664

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159069.4 → XP_005159126.1 guanine nucleotide-binding protein G(o) subunit alpha isoform X1

UniProtKB/TrEMBL

A0A8M2B616, F8W442

Related

ENSDARP00000124253.1, ENSDART00000150106.3

Conserved Domains (2) summary

cd00066
Location:34 → 348

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

smart00275
Location:14 → 352

G_alpha; G protein alpha subunit
XM_005159071.4 → XP_005159128.1 guanine nucleotide-binding protein G(o) subunit alpha isoform X2

UniProtKB/TrEMBL

A0A8M2B604

Conserved Domains (2) summary

cd00066
Location:34 → 294

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

smart00275
Location:14 → 293

G_alpha; G protein alpha subunit