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ppp1r14ab protein phosphatase 1, regulatory (inhibitor) subunit 14Ab [ Danio rerio (zebrafish) ]

Gene ID: 393783, updated on 27-Mar-2024

Summary

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Official Symbol
ppp1r14abprovided by ZNC
Official Full Name
protein phosphatase 1, regulatory (inhibitor) subunit 14Abprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1783
See related
Ensembl:ENSDARG00000017710 AllianceGenome:ZFIN:ZDB-GENE-040426-1783
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:73377
Summary
Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to act upstream of or within regulation of phosphorylation. Predicted to be located in cytoplasm. Is expressed in hindbrain neural plate; nervous system; neural tube; presumptive rhombomere 4; and ventral mesoderm. Orthologous to human PPP1R14A (protein phosphatase 1 regulatory inhibitor subunit 14A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ppp1r14ab in Genome Data Viewer
Location:
chromosome: 15
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (20204625..20233010, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (20268896..20297278, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 13b Neighboring gene exocyst complex component 3-like 2b Neighboring gene serine peptidase inhibitor, Kunitz type, 2 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The habenulo-raphe serotonergic circuit encodes an aversive expectation value essential for adaptive active avoidance of danger. Amo R, et al. Neuron, 2014 Dec 3. PMID 25467985
  2. TALE factors poise promoters for activation by Hox proteins. Choe SK, et al. Dev Cell, 2014 Jan 27. PMID 24480644, Free PMC Article
  3. A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Choe SK, et al. Dev Biol, 2011 Oct 15. PMID 21787765, Free PMC Article
  4. The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. Lang I, et al. Int J Mol Sci, 2020 Aug 9. PMID 32784920, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC73377

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1, regulatory (inhibitor) subunit 14Ab
Names
ppp1r14al

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200810.1 → NP_957104.1  protein phosphatase 1, regulatory (inhibitor) subunit 14Ab

    See identical proteins and their annotated locations for NP_957104.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059686
    UniProtKB/TrEMBL
    Q6PBJ4
    Related
    ENSDARP00000112264.2, ENSDART00000123910.3
    Conserved Domains (1) summary
    pfam05361
    Location:1 → 139
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    20204625..20233010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021481361.1 → XP_021337036.1  protein phosphatase 1, regulatory (inhibitor) subunit 14Ab isoform X1

    UniProtKB/TrEMBL
    A0A8M9QLB3
    Conserved Domains (1) summary
    pfam05361
    Location:4 → 77
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394946.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    78088..116833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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