nt5e 5'-nucleotidase, ecto (CD73) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nt5eprovided by ZNC
Official Full Name: 5'-nucleotidase, ecto (CD73)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1261
See related: Ensembl:ENSDARG00000071017 AllianceGenome:ZFIN:ZDB-GENE-040426-1261
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63784
Summary: Predicted to enable 5'-nucleotidase activity. Acts upstream of or within response to copper ion. Predicted to be located in membrane. Predicted to be anchored component of membrane. Predicted to be active in plasma membrane. Is expressed in brain and intestinal bulb. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (826459..848068)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (805633..827242)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

enzymatic properties of an ecto-5'-nucleotidase activity in brain membranes of zebrafish
Title: Ecto-5'-nucleotidase activity in brain membranes of zebrafish (Danio rerio).

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 5'-nucleotidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-nucleotidase activity	IEA Inferred from Electronic Annotation more info
enables XMP 5'-nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in AMP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nucleotide catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to copper ion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5'-nucleotidase

NP_957226.1

EC 3.1.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200932.1 → NP_957226.1 5'-nucleotidase precursor

See identical proteins and their annotated locations for NP_957226.1

Status: PROVISIONAL

Source sequence(s)

BC055243

UniProtKB/TrEMBL

Q7SXU4

Related

ENSDARP00000095510.3, ENSDART00000104740.4

Conserved Domains (3) summary

COG0737
Location:23 → 525

UshA; 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family [Nucleotide transport and metabolism, Defense mechanisms]

cd07409
Location:27 → 307

MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain

pfam02872
Location:335 → 505

5_nucleotid_C; 5'-nucleotidase, C-terminal domain