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ing3 inhibitor of growth family, member 3 [ Danio rerio (zebrafish) ]

Gene ID: 393911, updated on 27-Mar-2024

Summary

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Official Symbol
ing3provided by ZNC
Official Full Name
inhibitor of growth family, member 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-040109-3
See related
Ensembl:ENSDARG00000034326 AllianceGenome:ZFIN:ZDB-GENE-040109-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56327
Summary
Predicted to enable methylated histone binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within chromatin organization and regulation of growth. Predicted to be located in nucleus. Predicted to be part of NuA4 histone acetyltransferase complex. Orthologous to human ING3 (inhibitor of growth family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See ing3 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (10604126..10615355)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (10605277..10616506)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, Shal-related subfamily, member 2 Neighboring gene tetraspanin 12 Neighboring gene cadherin-like and PC-esterase domain containing 1 Neighboring gene wingless-type MMTV integration site family, member 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Phylogenetic analysis of the ING family of PHD finger proteins. He GH, et al. Mol Biol Evol, 2005 Jan. PMID 15356280
  2. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
  3. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC56327

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inhibitor of growth protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200937.2 → NP_957231.1  inhibitor of growth protein 3

    See identical proteins and their annotated locations for NP_957231.1

    Status: VALIDATED

    Source sequence(s)
    AL929016, BX897748
    UniProtKB/TrEMBL
    A0A8M1PC08, Q6TEM2
    Related
    ENSDARP00000031200.5, ENSDART00000037140.7
    Conserved Domains (3) summary
    COG5034
    Location:4 → 408
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15585
    Location:360 → 404
    PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
    pfam12998
    Location:3 → 102
    ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    10604126..10615355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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