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atp2a2a ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a [ Danio rerio (zebrafish) ]

Gene ID: 393940, updated on 19-May-2024

Summary

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Official Symbol
atp2a2aprovided by ZNC
Official Full Name
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-702
See related
Ensembl:ENSDARG00000029439 AllianceGenome:ZFIN:ZDB-GENE-040426-702
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
atp2a2; zgc:55380
Summary
Predicted to enable P-type calcium transporter activity. Acts upstream of or within heart looping and regulation of heart contraction. Predicted to be located in membrane and sarcoplasmic reticulum. Predicted to be integral component of membrane. Is expressed in cardiovascular system; musculature system; pectoral fin; polster; and somite. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See atp2a2a in Genome Data Viewer
Location:
chromosome: 8
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (11687231..11744993)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (11649533..11707288)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene formin binding protein 1a Neighboring gene intraflagellar transport 81 homolog Neighboring gene anaphase promoting complex subunit 7 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparison of the acute effects of benzo-a-pyrene on adult zebrafish (Danio rerio) cardiorespiratory function following intraperitoneal injection versus aqueous exposure. Gerger CJ, et al. Aquat Toxicol, 2015 Aug. PMID 26005921
  2. Regulation of the sarcoplasmic reticulum calcium pump by divergent phospholamban isoforms in zebrafish. Gorski PA, et al. J Biol Chem, 2015 Mar 13. PMID 25593315, Free PMC Article
  3. Aerobic metabolism and cardiac activity in the descendants of zebrafish exposed to pyrolytic polycyclic aromatic hydrocarbons. Lucas J, et al. Environ Sci Pollut Res Int, 2014 Dec. PMID 24994101
  4. Thyroid hormone regulates cardiac performance during cold acclimation in zebrafish (Danio rerio). Little AG, et al. J Exp Biol, 2014 Mar 1. PMID 24265422
  5. Nesfatin-1-like peptide is a negative regulator of cardiovascular functions in zebrafish and goldfish. Sundarrajan L, et al. Gen Comp Endocrinol, 2021 Nov 1. PMID 34453930

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC55380

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type calcium transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cardiac muscle contraction by calcium ion signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Names
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a
serca2
NP_957259.1
XP_005166855.1
XP_005166856.1
XP_021333895.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200965.1 → NP_957259.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2

    See identical proteins and their annotated locations for NP_957259.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045327
    UniProtKB/TrEMBL
    Q7ZW18
    Related
    ENSDARP00000042039.6, ENSDART00000042040.8
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 987
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:93 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:782 → 985
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 710
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 526
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    11687231..11744993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478220.1 → XP_021333895.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QII7
    Conserved Domains (1) summary
    cd02083
    Location:5 → 987
    P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3

  2. XM_005166798.4 → XP_005166855.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1

    See identical proteins and their annotated locations for XP_005166855.1

    UniProtKB/TrEMBL
    A0A8M2BEU8, A9C3Q4
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 987
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:93 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:782 → 985
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 710
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 526
    Cation_ATPase; Cation transport ATPase (P-type)

  3. XM_005166799.4 → XP_005166856.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1

    See identical proteins and their annotated locations for XP_005166856.1

    UniProtKB/TrEMBL
    A0A8M2BEU8, A9C3Q4
    Related
    ENSDARP00000113858.1, ENSDART00000146241.2
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 987
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:93 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:782 → 985
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 710
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 526
    Cation_ATPase; Cation transport ATPase (P-type)
Nucleotide Protein Strain
Heading Accession and Version

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