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nck2a NCK adaptor protein 2a [ Danio rerio (zebrafish) ]

Gene ID: 393972, updated on 26-May-2024

Summary

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Official Symbol
nck2aprovided by ZNC
Official Full Name
NCK adaptor protein 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-686
See related
Ensembl:ENSDARG00000018206 AllianceGenome:ZFIN:ZDB-GENE-040426-686
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Nck2; zgc:55283
Summary
Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Predicted to be involved in several processes, including cell migration; regulation of response to endoplasmic reticulum stress; and regulation of translation. Predicted to act upstream of or within actin filament bundle assembly; barbed-end actin filament capping; and regulation of translation. Predicted to be located in cytosol and endoplasmic reticulum. Is expressed in rhombomere 3 and rhombomere 5. Orthologous to human NCK2 (NCK adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See nck2a in Genome Data Viewer
Location:
chromosome: 9
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (6395137..6502149, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (6417152..6524194, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene UDP-glucuronate decarboxylase 1 Neighboring gene ECRG4 augurin precursor a Neighboring gene si:dkeyp-118h3.6 Neighboring gene four and a half LIM domains 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Nongenomic effects and mechanistic study of butyl benzyl phthalate-induced thyroid disruption: Based on integrated in vitro, in silico assays and proteome analysis. Li J, et al. Sci Total Environ, 2022 Aug 25. PMID 35525365
  2. Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. Cosse-Etchepare C, et al. Int J Dev Biol, 2018. PMID 29877572
  3. A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Choe SK, et al. Dev Biol, 2011 Oct 15. PMID 21787765, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC55283

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of PERK-mediated unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translation in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytoplasmic protein NCK2; cytoplasmic protein NCK2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200997.1 → NP_957291.1  cytoplasmic protein NCK2a

    See identical proteins and their annotated locations for NP_957291.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046872
    UniProtKB/TrEMBL
    Q803A2
    Related
    ENSDARP00000093447.3, ENSDART00000102672.6
    Conserved Domains (4) summary
    cd10409
    Location:306 → 403
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11766
    Location:122 → 174
    SH3_Nck_2; Second Src Homology 3 domain of Nck adaptor proteins
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:217 → 275
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    6395137..6502149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009304471.3 → XP_009302746.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q4I8, F1R1C3
    Conserved Domains (4) summary
    cd10409
    Location:306 → 403
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11766
    Location:122 → 174
    SH3_Nck_2; Second Src Homology 3 domain of Nck adaptor proteins
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:217 → 275
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  2. XM_021478633.1 → XP_021334308.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q4I8, F1R1C3
    Conserved Domains (4) summary
    cd10409
    Location:306 → 403
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11766
    Location:122 → 174
    SH3_Nck_2; Second Src Homology 3 domain of Nck adaptor proteins
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:217 → 275
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein
Nucleotide Protein Strain
Heading Accession and Version

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