ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: ATP1A1provided by VGNC
Official Full Name: ATPase Na+/K+ transporting subunit alpha 1provided by VGNC
Primary source: VGNC:VGNC:98735
See related: Ensembl:ENSSSCG00000006740
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Broad expression in kidney (RPKM 808.2), heart (RPKM 235.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	4	NC_010446.5 (104353506..104384321, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	4	NC_010446.4 (114431993..114451892, complement)

Chromosome 4 - NC_010446.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Alpha-1 Subunit of the Na[+]/K[+]-ATPase (ATP1A1) Is a Host Factor Involved in the Attachment of Porcine Epidemic Diarrhea Virus.
Title: The Alpha-1 Subunit of the Na(+)/K(+)-ATPase (ATP1A1) Is a Host Factor Involved in the Attachment of Porcine Epidemic Diarrhea Virus.
Data suggest that bufadienolides harbor qualitative chemical differences from cardenolides with respect to the Na(+)/K(+)-ATPase (NKA) conformations to which they can bind.
Title: Conformational states of the pig kidney Na(+)/K(+)-ATPase differently affect bufadienolides and cardenolides: A directed structure-activity and structure-kinetics study.
The extracellular entrance to the binding site on Sodium-Potassium-Exchanging ATPase has been characterized using spin-labeled derivatives of cardiotonic steroids.
Title: Spin-labeled derivatives of cardiotonic steroids as tools for characterization of the extracellular entrance to the binding site on Na(+) ,K(+) -ATPase.
This study determined the specificity of the interaction between the N-terminus of the alpha-subunit of the Na+,K+-ATPase and the surrounding membrane.
Title: Interaction of N-terminal peptide analogues of the Na(+),K(+)-ATPase with membranes.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase activity and SFK signaling.
Title: Src Family Kinase Links Insulin Signaling to Short Term Regulation of Na,K-ATPase in Nonpigmented Ciliary Epithelium.
Uroguanylin modulates (Na++K+)ATPase in a proximal tubule cells via cGMP/protein kinase G, cAMP/protein kinase A, and mTOR pathways.
Title: Uroguanylin modulates (Na++K+)ATPase in a proximal tubule cell line: Interactions among the cGMP/protein kinase G, cAMP/protein kinase A, and mTOR pathways.
Data indicate that magnesium fluoride, magnesium fluoride and Na,K-ATPase form a very stable complex in the E2 conformation.
Title: The E2P-like state induced by magnesium fluoride complexes in the Na,K-ATPase. Kinetics of formation and interaction with Rb(+).
Data indicate that Rb(+) can be occluded through Na(+)/K(+)-ATPase cycling mode that takes place in the absence of Na(+) ions.
Title: Alternative cycling modes of the Na(+)/K(+)-ATPase in the presence of either Na(+) or Rb(+).
Expression of mutant alpha1 Na/K-ATPase defective in conformational transition attenuates Src-mediated signal transduction
Title: Expression of mutant α1 Na/K-ATPase defective in conformational transition attenuates Src-mediated signal transduction.
re-arrangements of the Na+,K+-ATPase stabilized by cardiotonic steroids may affect protein-protein interactions within the intracellular signal transduction networks
Title: Structural insights into the high affinity binding of cardiotonic steroids to the Na+,K+-ATPase.

Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Markers

Atp1a1 (e-PCR), detects polymorphism
- UniSTS:546665

A001Z44 (e-PCR)
- UniSTS:66284

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info	PubMed
enables P-type sodium:potassium-exchanging transporter activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular potassium ion homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular sodium ion homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in potassium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sodium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: sodium/potassium-transporting ATPase subunit alpha-1

Names: (Na+, K+)-ATPase alpha-subunit; Na(+)/K(+) ATPase alpha-1 subunit; Na+ /K+ ATPase alpha 1 subunit; Na+/K+ transporting alpha 1 polypeptide; sodium pump subunit alpha-1

NP_999414.1

EC 7.2.2.13

XP_020944376.1

EC 7.2.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214249.1 → NP_999414.1 sodium/potassium-transporting ATPase subunit alpha-1

See identical proteins and their annotated locations for NP_999414.1

Status: PROVISIONAL

Source sequence(s)

X03938

UniProtKB/Swiss-Prot

P05024, P18874

UniProtKB/TrEMBL

A0A4X1SUL4, D2WKD6

Related

ENSSSCP00000072723.2, ENSSSCT00000072858.2

Conserved Domains (1) summary

TIGR01106
Location:25 → 1021

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010446.5 Reference Sscrofa11.1 Primary Assembly

Range

104353506..104384321 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021088717.1 → XP_020944376.1 sodium/potassium-transporting ATPase subunit alpha-1 isoform X1

UniProtKB/TrEMBL

A0A4X1SWE3, A0A5G2QZU7, F1SAX3

Related

ENSSSCP00000070396.1, ENSSSCT00000087750.2

Conserved Domains (1) summary

TIGR01106
Location:25 → 1021

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit