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itih2 inter-alpha-trypsin inhibitor heavy chain 2 [ Danio rerio (zebrafish) ]

Gene ID: 406280, updated on 27-Mar-2024

Summary

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Official Symbol
itih2provided by ZNC
Official Full Name
inter-alpha-trypsin inhibitor heavy chain 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1942
See related
Ensembl:ENSDARG00000045516 AllianceGenome:ZFIN:ZDB-GENE-040426-1942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56119; id:ibd5015; wu:fb34d10; wu:fb96f01; DKEY-235I4.1
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within hyaluronan metabolic process and negative regulation of peptidase activity. Predicted to be located in extracellular region. Is expressed in ball; extension; liver; and yolk syncytial layer. Orthologous to human ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See itih2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (25187912..25215968, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (25198714..25226770, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto Neighboring gene ATP synthase F1 subunit gamma Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene inter-alpha-trypsin inhibitor heavy chain 5 Neighboring gene transmembrane protein 110, like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression and localization of grass carp pkc-θ (protein kinase C theta) gene after its activation. Mehjabin R, et al. Fish Shellfish Immunol, 2019 Apr. PMID 30716520
  2. Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity. Jima DD, et al. Mol Immunol, 2009 Apr. PMID 19200601, Free PMC Article
  3. What makes a bad egg? Egg transcriptome reveals dysregulation of translational machinery and novel fertility genes important for fertilization. Cheung CT, et al. BMC Genomics, 2019 Jul 15. PMID 31307377, Free PMC Article
  4. HNF factors form a network to regulate liver-enriched genes in zebrafish. Cheng W, et al. Dev Biol, 2006 Jun 15. PMID 16631158
  5. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hyaluronan metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inter-alpha-trypsin inhibitor heavy chain H2
Names
inter-alpha (globulin) inhibitor H2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327825.1 → NP_001314754.1  inter-alpha-trypsin inhibitor heavy chain H2 precursor

    Status: VALIDATED

    Source sequence(s)
    BX537116, BX640594
    UniProtKB/TrEMBL
    A0A8M1P9D4, Q5RH29
    Related
    ENSDARP00000066932.4, ENSDART00000066933.6
    Conserved Domains (4) summary
    TIGR03788
    Location:72 → 645
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam06668
    Location:736 → 921
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    cl00057
    Location:302 → 482
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl02699
    Location:61 → 180
    VIT; Vault protein inter-alpha-trypsin domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    25187912..25215968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_213007.1: Suppressed sequence

    Description
    NM_213007.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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