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plekha1a pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1a [ Danio rerio (zebrafish) ]

Gene ID: 406745, updated on 25-Apr-2024

Summary

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Official Symbol
plekha1aprovided by ZNC
Official Full Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2780
See related
Ensembl:ENSDARG00000030064 AllianceGenome:ZFIN:ZDB-GENE-040426-2780
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc34a05; fc57h12; plekha1; zgc:55676; wu:fc34a05; wu:fc57h12
Summary
Predicted to enable PDZ domain binding activity. Predicted to be active in cytoplasm and membrane. Orthologous to human PLEKHA1 (pleckstrin homology domain containing A1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See plekha1a in Genome Data Viewer
Location:
chromosome: 17
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (21887823..21913328)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (21867987..21893492)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene deleted in malignant brain tumors 1 protein-like Neighboring gene deleted in malignant brain tumors 1 protein-like Neighboring gene CUB and zona pellucida-like domains 1, tandem duplicate 1 Neighboring gene HtrA serine peptidase 1a Neighboring gene cysteine-rich protein 3 Neighboring gene solute carrier family 22 member 7b, tandem duplicate 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables PDZ domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family A member 1; pleckstrin homology domain-containing family A member 1a
Names
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213436.1 → NP_998601.1  pleckstrin homology domain-containing family A member 1a

    See identical proteins and their annotated locations for NP_998601.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044452
    UniProtKB/TrEMBL
    Q7ZYX2
    Related
    ENSDARP00000133411.2, ENSDART00000165192.2
    Conserved Domains (3) summary
    cd13270
    Location:1 → 118
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:184 → 297
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:191 → 287
    PH; PH domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    21887823..21913328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158692.3 → XP_005158749.1  pleckstrin homology domain-containing family A member 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B5K1
    Conserved Domains (3) summary
    cd13270
    Location:1 → 118
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:184 → 297
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:191 → 287
    PH; PH domain

  2. XM_009293023.3 → XP_009291298.1  pleckstrin homology domain-containing family A member 1 isoform X3

    See identical proteins and their annotated locations for XP_009291298.1

    UniProtKB/TrEMBL
    A0A8M3AU84
    Conserved Domains (3) summary
    cd13270
    Location:1 → 118
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:184 → 297
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:191 → 287
    PH; PH domain

  3. XM_009293024.3 → XP_009291299.1  pleckstrin homology domain-containing family A member 1 isoform X3

    See identical proteins and their annotated locations for XP_009291299.1

    UniProtKB/TrEMBL
    A0A8M3AU84
    Conserved Domains (3) summary
    cd13270
    Location:1 → 118
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:184 → 297
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:191 → 287
    PH; PH domain

  4. XM_017351618.2 → XP_017207107.1  pleckstrin homology domain-containing family A member 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YVK6, E9QH37
    Related
    ENSDARP00000122375.1, ENSDART00000131929.3

RNA

  1. XR_222431.4 RNA Sequence

  2. XR_002455898.1 RNA Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394986.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    135393..160862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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