tbpl2 TATA box binding protein like 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tbpl2provided by ZNC
Official Full Name: TATA box binding protein like 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040520-3
See related: Ensembl:ENSDARG00000097302 AllianceGenome:ZFIN:ZDB-GENE-040520-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tbp2; trf3
Summary: Enables DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in embryo development; embryonic pattern specification; and hemopoiesis. Acts upstream of or within DNA-templated transcription, initiation. Predicted to be located in nucleus. Is expressed in margin. Orthologous to human TBPL2 (TATA-box binding protein like 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (10738100..10747554)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (10582031..10591522)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that like Trf3-depleted zebrafish embryos, Taf3-depleted embryos exhibit multiple developmental defects and fail to undergo hematopoiesis.
Title: Selective interaction between Trf3 and Taf3 required for early development and hematopoiesis.
Zebrafish embryos depleted of Trf3 or Mespa also failed to express cdx4, a caudal-related gene required for haematopoiesis
Title: Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3.
the requirement of TBP2 for embryonic patterning
Title: TBP2, a vertebrate-specific member of the TBP family, is required in embryonic development of zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA-templated transcription initiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: TATA box-binding protein-like 2; TATA box-binding protein-like protein 2

Names: TATA-binding protein 2; TBP-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214796.1 → NP_999961.1 TATA box-binding protein-like 2

See identical proteins and their annotated locations for NP_999961.1

Status: PROVISIONAL

Source sequence(s)

AY256970

UniProtKB/Swiss-Prot

Q1JPY4, Q6X484

Related

ENSDARP00000051526.3, ENSDART00000051527.5

Conserved Domains (2) summary

PLN00062
Location:136 → 311

PLN00062; TATA-box-binding protein; Provisional

cd04516
Location:136 → 309

TBP_eukaryotes; eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

10738100..10747554

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005169810.4 → XP_005169867.1 TATA box-binding protein-like protein 2 isoform X1

UniProtKB/Swiss-Prot

Q1JPY4, Q6X484

UniProtKB/TrEMBL

A0A8M2BH15

Conserved Domains (2) summary

PLN00062
Location:136 → 312

PLN00062; TATA-box-binding protein; Provisional

cd04516
Location:136 → 310

TBP_eukaryotes; eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation ...