zp3a.1 zona pellucida glycoprotein 3a, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: zp3a.1provided by ZNC
Official Full Name: zona pellucida glycoprotein 3a, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040727-1
See related: Ensembl:ENSDARG00000042129 AllianceGenome:ZFIN:ZDB-GENE-040727-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pou3; zp3a; zpc1-1
Summary: Predicted to enable acrosin binding activity. Predicted to be involved in binding activity of sperm to zona pellucida; egg coat formation; and positive regulation of acrosome reaction. Predicted to be located in extracellular space and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix. Orthologous to several human genes including ZP3 (zona pellucida glycoprotein 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (33991800..33993770)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (34088922..34090891)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acrosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of egg coat	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in egg coat formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of acrosome reaction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in egg coat	IEA Inferred from Electronic Annotation more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zona pellucida glycoprotein 3a; zona pellucida sperm-binding protein 3a.1

Names: POU domain gene 3; zona pellucida glycoprotein 3a.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013271.1 → NP_001013289.1 zona pellucida sperm-binding protein 3a.1 precursor

Status: PROVISIONAL

Source sequence(s)

CR318619

UniProtKB/TrEMBL

A0A8M1N4F0, Q5TYP5

Related

ENSDARP00000061743.5, ENSDART00000061744.7

Conserved Domains (2) summary

smart00241
Location:126 → 382

ZP; Zona pellucida (ZP) domain

pfam00100
Location:244 → 381

Zona_pellucida; Zona pellucida-like domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

33991800..33993770

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160658.4 → XP_005160715.1 zona pellucida glycoprotein 3a isoform X1

UniProtKB/TrEMBL

A0A8M2B7J9

Conserved Domains (2) summary

smart00241
Location:126 → 382

ZP; Zona pellucida (ZP) domain

pfam00100
Location:244 → 381

Zona_pellucida; Zona pellucida-like domain