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RhoL Rho-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41136, updated on 10-May-2024

Summary

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Official Symbol
RhoLprovided by FlyBase
Official Full Name
Rho-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0014380
Locus tag
Dmel_CG9366
See related
AllianceGenome:FB:FBgn0014380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
9366; anon-EST:CL1c2; CG9366; D-RhoL; Dmel\CG9366; DmRHO-L; Drac3; DRhoL; G; Mes1; Rac3; RhoG; rhol; rhoL; Rhol; RhoL/Rac3; rol
Summary
Predicted to enable GTPase activity. Involved in several processes, including border follicle cell migration; hemocyte development; and hemocyte migration. Is expressed in several structures, including embryonic epidermis; gastrula embryo; hemocyte; mesoderm anlage; and plasmatocyte primordium. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See RhoL in Genome Data Viewer
Location:
85D18-85D18; 3-48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9497101..9502581, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5322823..5328303, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45203 Neighboring gene phurba tashi Neighboring gene uncharacterized protein Neighboring gene rumpelstiltskin Neighboring gene Ras oncogene at 85D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons. Emoto K, et al. Cell, 2004 Oct 15. PMID 15479641
  2. Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis. Murphy AM, et al. J Cell Biol, 1996 May. PMID 8636236, Free PMC Article
  3. The p21-activated kinase Mbt is a component of the apical protein complex in central brain neuroblasts and controls cell proliferation. Melzer J, et al. Development, 2013 May. PMID 23571212
  4. Forgetting is regulated through Rac activity in Drosophila. Shuai Y, et al. Cell, 2010 Feb 19. PMID 20178749
  5. Rho GTPases and cell migration. Ridley AJ. J Cell Sci, 2001 Aug. PMID 11683406

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hemocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hemocyte migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in melanotic encapsulation of foreign target IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mesoderm development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rho-like
Names
CG9366-PA
CG9366-PB
Rho-Like
RhoL-PA
RhoL-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9497101..9502581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260074.1 → NP_001247003.1  Rho-like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247003.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMW7
    Conserved Domains (2) summary
    smart00174
    Location:38 → 202
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd00157
    Location:36 → 198
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  2. NM_079568.3 → NP_524292.1  Rho-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524292.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24192, Q541G3, Q9U5D4, Q9VHC9
    Related
    FBpp0081602
    Conserved Domains (2) summary
    smart00174
    Location:14 → 178
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd00157
    Location:12 → 174
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3DMW7 D3DMW7
Q24192.1 Q24192

Gene LinkOut

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