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HtrA2 - HTRA2-related serine protease

Enables serine-type endopeptidase activity. Involved in several processes, including ectopic germ cell programmed cell death; positive regulation of cysteine-type endopeptidase activity; and spermatogenesis. Located in Nebenkern; cytosol; and mitochondrial intermembrane space. Is expressed in adult head and organism. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 8; CADASIL (multiple); hypertension; macular degeneration (multiple); and neurodegenerative disease (multiple). Orthologous to several human genes including HTRA2 (HtrA serine peptidase 2). [provided by Alliance of Genome Resources, Apr 2022]

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Species Gene Architecture aa