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CG12241 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41834, updated on 10-May-2024

Summary

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Official Symbol
CG12241provided by FlyBase
Primary source
FLYBASE:FBgn0038304
Locus tag
Dmel_CG12241
See related
AllianceGenome:FB:FBgn0038304
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG12241
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in cytosol. Orthologous to human SGSM3 (small G protein signaling modulator 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See CG12241 in Genome Data Viewer
Location:
88E3-88E3; 3-56 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15219256..15222371)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11044978..11048093)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Mau2 sister chromatid cohesion factor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Shal Interactor of Di-Leucine Motif Neighboring gene mir-9383 stem loop Neighboring gene RNA polymerase II subunit G Neighboring gene uncharacterized protein Neighboring gene Chromatin assembly factor 1, p55 subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RUN domains: a new family of domains involved in Ras-like GTPase signaling. Callebaut I, et al. Trends Biochem Sci, 2001 Feb. PMID 11166556
  2. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
  3. Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency. Cheli VT, et al. Hum Mol Genet, 2010 Mar 1. PMID 20015953, Free PMC Article
  4. Evi5 promotes collective cell migration through its Rab-GAP activity. Laflamme C, et al. J Cell Biol, 2012 Jul 9. PMID 22778279, Free PMC Article
  5. Differential evolutionary wiring of the tyrosine kinase Btk. Nawaz HM, et al. PLoS One, 2012. PMID 22574122, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12241-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15219256..15222371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142175.3 → NP_650432.1  uncharacterized protein Dmel_CG12241 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650432.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VFB6
    Related
    FBpp0082510
    Conserved Domains (3) summary
    cd11813
    Location:540 → 592
    SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
    smart00164
    Location:161 → 375
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam02759
    Location:619 → 773
    RUN; RUN domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VFB6 Q9VFB6

Gene LinkOut

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