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ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 [ Gallus gallus (chicken) ]

Gene ID: 427971, updated on 5-Mar-2024

Summary

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Symbol
ADAMTS5provided by CGNC
Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 5provided by CGNC
Primary source
CGNC:11783
See related
Ensembl:ENSGALG00010010712
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See ADAMTS5 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
8
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (103163967..103210607, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (103251931..103298523, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene cysteine and tyrosine rich 1 Neighboring gene uncharacterized LOC124417328 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 1 Neighboring gene uncharacterized LOC124417635 Neighboring gene uncharacterized LOC121109151

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 5
Names
ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    103163967..103210607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_425541.8 → XP_425541.6  A disintegrin and metalloproteinase with thrombospondin motifs 5

    UniProtKB/TrEMBL
    A0A8V0Y665, F1P3S7
    Related
    ENSGALP00010014452.1, ENSGALT00010025644.1
    Conserved Domains (3) summary
    smart00209
    Location:516 → 568
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:215 → 419
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:678 → 798
    ADAM_spacer1; ADAM-TS Spacer 1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    103251931..103298523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040658789.2 → XP_040514723.1  A disintegrin and metalloproteinase with thrombospondin motifs 5

    UniProtKB/TrEMBL
    A0A8V0Y665, F1P3S7
    Conserved Domains (3) summary
    smart00209
    Location:516 → 568
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:215 → 419
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:678 → 798
    ADAM_spacer1; ADAM-TS Spacer 1
Nucleotide Protein
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