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5-HT7 5-hydroxytryptamine (serotonin) receptor 7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43669, updated on 10-May-2024

Summary

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Official Symbol
5-HT7provided by FlyBase
Official Full Name
5-hydroxytryptamine (serotonin) receptor 7provided by FlyBase
Primary source
FLYBASE:FBgn0004573
Locus tag
Dmel_CG12073
See related
AllianceGenome:FB:FBgn0004573
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
5-HT-7; 5-HT-dro; 5-HT-dro1; 5-HT2A; 5-HT7Dro; 5-HTdro1; 5-HT[7]Dro; 5-HT[[7Dro]]; 5-HT[[7]]; 5-HT[[7]]Dro; 5-HT[[7]]R; 5-HT[[dro1]]; 5HT-7; 5HT-dro; 5HT-dro1; 5HT-R1; 5HT7; 5htdror; 5HT[[7Dro]]; CG12073; Dm5-HT7; Dm5-HT[[7]]; Dm5HTdro1; Dmel\CG12073; DRO1; HT7
Summary
Enables G protein-coupled serotonin receptor activity. Involved in mating behavior and serotonin receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in adult head; central nervous system; embryonic/larval midgut interstitial cell; larval midline neurons; and ventral midline of embryo. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to several human genes including HTR7 (5-hydroxytryptamine receptor 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See 5-HT7 in Genome Data Viewer
Location:
100B1-100B1; 3-102 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30968236..31016875, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26793958..26842597, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Copper transporter 1C Neighboring gene long non-coding RNA:CR46116 Neighboring gene long non-coding RNA:CR46117 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Calcineurin A1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Serotonin receptor 5-HT7 in Drosophila mushroom body neurons mediates larval appetitive olfactory learning. Ganguly A, et al. Sci Rep, 2020 Dec 4. PMID 33277559, Free PMC Article
  2. Cloning and characterization of a Drosophila serotonin receptor that activates adenylate cyclase. Witz P, et al. Proc Natl Acad Sci U S A, 1990 Nov. PMID 2174167, Free PMC Article
  3. Expression of the Human Serotonin 5-HT(7) Receptor Rescues Phenotype Profile and Restores Dysregulated Biomarkers in a Drosophila melanogaster Glioma Model. Courant F, et al. Cells, 2022 Apr 9. PMID 35455961, Free PMC Article
  4. Serotonergic neurons respond to nutrients and regulate the timing of steroid hormone biosynthesis in Drosophila. Shimada-Niwa Y, et al. Nat Commun, 2014 Dec 15. PMID 25502946, Free PMC Article
  5. Cell-specific manipulation of second messengers; a toolbox for integrative physiology in Drosophila. Kerr M, et al. Curr Biol, 2004 Aug 24. PMID 15324663

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 5-HT(7)Dro activity is essential for normal courtship and mating behaviors in the fly
    Title: The serotonin 5-HT7Dro receptor is expressed in the brain of Drosophila, and is essential for normal courtship and mating.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled amine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled serotonin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables G protein-coupled serotonin receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating serotonin receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in courtship behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female mating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior, orientation prior to leg tapping and wing vibration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior, proboscis-mediated licking IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior, veined wing vibration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male mating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in serotonin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in serotonin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
5-hydroxytryptamine (serotonin) receptor 7
Names
5-HT7-PA
5-HT7-PB
CG12073-PA
CG12073-PB
serotonin receptor
serotonin receptor 1
serotonin receptor 7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30968236..31016875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276202.1 → NP_001263131.1  5-hydroxytryptamine (serotonin) receptor 7, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263131.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P20905, Q9VA21
    UniProtKB/TrEMBL
    A0A0B4KHG3
    Conserved Domains (2) summary
    pfam00001
    Location:179 → 507
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:173 → 342
    7tm_4; Olfactory receptor

  2. NM_079860.3 → NP_524599.1  5-hydroxytryptamine (serotonin) receptor 7, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524599.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P20905, Q9VA21
    UniProtKB/TrEMBL
    A0A0B4KHG3
    Related
    FBpp0085108
    Conserved Domains (2) summary
    pfam00001
    Location:179 → 507
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:173 → 342
    7tm_4; Olfactory receptor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHG3 A0A0B4KHG3
P20905.1 P20905

Gene LinkOut

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