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Chchd3 Coiled-coil-helix-coiled-coil-helix domain containing 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43672, updated on 10-May-2024

Summary

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Official Symbol
Chchd3provided by FlyBase
Official Full Name
Coiled-coil-helix-coiled-coil-helix domain containing 3provided by FlyBase
Primary source
FLYBASE:FBgn0010808
Locus tag
Dmel_CG1715
See related
AllianceGenome:FB:FBgn0010808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0205/14; 0353/13; 0812/02; 0966/01; 1274/08; anon-l; CG1715; ChChd3; Dmel\CG1715; dMIC19; l(3)03670; l(3)3670; l(3)96601; l(3)S127408; pMY8; x94917
Summary
Involved in cristae formation and mitochondrial fusion. Located in mitochondrial inner membrane. Is expressed in several structures, including anterior endoderm; embryonic/larval muscle system; extended germ band embryo; gut section; and wing disc. Orthologous to several human genes including CHCHD3 (coiled-coil-helix-coiled-coil-helix domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Chchd3 in Genome Data Viewer
Location:
100B1-100B1; 3-102 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31052616..31053915, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26878338..26879637, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Calcineurin A1 Neighboring gene pseudo Neighboring gene mir-4948 stem loop Neighboring gene Alkaline phosphatase 4 Neighboring gene discs overgrown Neighboring gene Sox100B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Kloss B, et al. Cell, 1998 Jul 10. PMID 9674431
  2. A novel Drosophila alkaline phosphatase specific to the ellipsoid body of the adult brain and the lower Malpighian (renal) tubule. Yang MY, et al. Genetics, 2000 Jan. PMID 10628988, Free PMC Article
  3. Cross-Talk Between Mitochondrial Fusion and the Hippo Pathway in Controlling Cell Proliferation During Drosophila Development. Deng Q, et al. Genetics, 2016 Aug. PMID 27317679, Free PMC Article
  4. double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs. Zilian O, et al. Development, 1999 Dec. PMID 10556065
  5. Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD. Li S, et al. Cell Rep, 2020 Aug 4. PMID 32755582, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cristae formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inner mitochondrial membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MICOS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Coiled-coil-helix-coiled-coil-helix domain containing 3
Names
CG1715-PA
Chchd3-PA
lethal (3) 03670

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31052616..31053915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143581.3 → NP_651838.1  Coiled-coil-helix-coiled-coil-helix domain containing 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651838.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24269, Q9VA18
    Related
    FBpp0085107
    Conserved Domains (2) summary
    pfam06747
    Location:163 → 195
    CHCH; CHCH domain
    pfam07956
    Location:103 → 193
    DUF1690; Protein of Unknown function (DUF1690)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24269 Q24269
Q9VA18 Q9VA18

Gene LinkOut

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