dffa DNA fragmentation factor, alpha polypeptide [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dffaprovided by ZNC
Official Full Name: DNA fragmentation factor, alpha polypeptideprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-376
See related: Ensembl:ENSDARG00000055770 AllianceGenome:ZFIN:ZDB-GENE-040718-376
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92229
Summary: Predicted to enable deoxyribonuclease inhibitor activity. Predicted to be involved in regulation of apoptotic process. Predicted to act upstream of or within apoptotic DNA fragmentation. Orthologous to human DFFA (DNA fragmentation factor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (28803007..28808480, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (28876466..28881939, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables deoxyribonuclease inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic DNA fragmentation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA fragmentation factor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002631.1 → NP_001002631.1 DNA fragmentation factor subunit alpha

See identical proteins and their annotated locations for NP_001002631.1

Status: PROVISIONAL

Source sequence(s)

BC075948

UniProtKB/TrEMBL

Q6DHM1

Related

ENSDARP00000072629.4, ENSDART00000078167.5

Conserved Domains (2) summary

pfam09033
Location:87 → 237

DFF-C; DNA Fragmentation factor 45kDa, C terminal domain

cl02541
Location:3 → 81

CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...