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mastl microtubule associated serine/threonine kinase-like [ Danio rerio (zebrafish) ]

Gene ID: 445215, updated on 27-Mar-2024

Summary

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Official Symbol
mastlprovided by ZNC
Official Full Name
microtubule associated serine/threonine kinase-likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040801-128
See related
Ensembl:ENSDARG00000055566 AllianceGenome:ZFIN:ZDB-GENE-040801-128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
GW; GWL; MAST-L; im:7149025; wu:fa02a12; zgc:100990
Summary
Predicted to enable protein phosphatase 2A binding activity and protein serine/threonine kinase activity. Acts upstream of or within thrombocyte differentiation. Predicted to be located in centrosome and cleavage furrow. Predicted to be active in nucleus. Is expressed in somite. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human MASTL (microtubule associated serine/threonine kinase like). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See mastl in Genome Data Viewer
Location:
chromosome: 24
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (5892932..5908247)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (5863805..5878918)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 1 Neighboring gene procollagen C-endopeptidase enhancer 2b Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 63 Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 64 Neighboring gene acyl-CoA binding domain containing 5a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. In vivo inactivation of MASTL kinase results in thrombocytopenia. Johnson HJ, et al. Exp Hematol, 2009 Aug. PMID 19460416, Free PMC Article
  2. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within thrombocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase greatwall
Names
microtubule-associated serine/threonine-protein kinase-like
NP_001003609.2
XP_021325814.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003609.2 → NP_001003609.2  serine/threonine-protein kinase greatwall

    Status: VALIDATED

    Source sequence(s)
    CT573382
    UniProtKB/Swiss-Prot
    Q6DBX4
    UniProtKB/TrEMBL
    A0A8M1N1C1, F1R778
    Related
    ENSDARP00000072407.4, ENSDART00000077941.5
    Conserved Domains (3) summary
    smart00220
    Location:23 → 185
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05610
    Location:18 → 213
    STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
    cl21453
    Location:630 → 851
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    5892932..5908247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470139.1 → XP_021325814.1  serine/threonine-protein kinase greatwall isoform X1

    UniProtKB/Swiss-Prot
    Q6DBX4
    UniProtKB/TrEMBL
    A0A8M9PLP4
    Conserved Domains (2) summary
    cd05610
    Location:18 → 213
    STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
    cl21453
    Location:630 → 858
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DBX4.1 GenPept UniProtKB/Swiss-Prot:Q6DBX4

Gene LinkOut

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