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aurka aurora kinase A [ Danio rerio (zebrafish) ]

Gene ID: 445246, updated on 30-Mar-2024

Summary

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Official Symbol
aurkaprovided by ZNC
Official Full Name
aurora kinase Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040801-161
See related
Ensembl:ENSDARG00000012485 AllianceGenome:ZFIN:ZDB-GENE-040801-161
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb37c10; fc02c02; wu:fb37c10; wu:fc02c02; zgc:100912
Summary
Predicted to enable histone serine kinase activity. Acts upstream of or within mitotic cell cycle. Predicted to be located in microtubule. Predicted to be part of chromosome passenger complex. Predicted to be active in spindle microtubule; spindle midzone; and spindle pole centrosome. Is expressed in several structures, including caudal fin; immature eye; nervous system; somite; and spinal cord neural tube. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Orthologous to human AURKA (aurora kinase A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See aurka in Genome Data Viewer
Location:
chromosome: 6
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (60125055..60139655)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (60130132..60144746)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene SLAIN motif family, member 1b Neighboring gene prostate transmembrane protein, androgen induced 1 Neighboring gene phosphoenolpyruvate carboxykinase 1 (soluble) Neighboring gene PRELI domain containing 3 Neighboring gene solute carrier family 32 member 1 Neighboring gene rho GTPase-activating protein 40-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. ALKBH3-dependent m(1)A demethylation of Aurora A mRNA inhibits ciliogenesis. Kuang W, et al. Cell Discov, 2022 Mar 11. PMID 35277482, Free PMC Article
  2. Subcellular drug targeting illuminates local kinase action. Bucko PJ, et al. Elife, 2019 Dec 24. PMID 31872801, Free PMC Article
  3. Rosmarinic acid plays a protective role in the embryogenesis of zebrafish exposed to food colours through its influence on aurora kinase A level. Swarnalatha Y, et al. Biomed Pharmacother, 2017 May. PMID 28320082
  4. CEP41-mediated ciliary tubulin glutamylation drives angiogenesis through AURKA-dependent deciliation. Ki SM, et al. EMBO Rep, 2020 Feb 5. PMID 31885126, Free PMC Article
  5. Depletion of Aurora-A in zebrafish causes growth retardation due to mitotic delay and p53-dependent cell death. Jeon HY, et al. FEBS J, 2013 Mar. PMID 23351126

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within centrosome cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within meiotic spindle organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic centrosome separation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
aurora kinase A
Names
serine/threonine-protein kinase 6
NP_001003640.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003640.2 → NP_001003640.1  aurora kinase A

    See identical proteins and their annotated locations for NP_001003640.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078304
    UniProtKB/TrEMBL
    Q6DBZ4
    Related
    ENSDARP00000021253.3, ENSDART00000008224.5
    Conserved Domains (2) summary
    smart00220
    Location:138 → 388
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14116
    Location:132 → 389
    STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    60125055..60139655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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