nutf2 nuclear transport factor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nutf2provided by ZNC
Official Full Name: nuclear transport factor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-77
See related: Ensembl:ENSDARG00000056531 AllianceGenome:ZFIN:ZDB-GENE-041010-77
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb40a01; wu:fb40a01; zgc:101555
Summary: Predicted to be involved in protein import into nucleus. Predicted to be part of nuclear pore central transport channel. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (21911337..21929492, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (21922271..21940385, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fk39h04.y1 (e-PCR)
- UniSTS:200967

z26472 (e-PCR), detects polymorphism
- UniSTS:238901

fb40a01.x1 (e-PCR)
- UniSTS:190561

fb40a01.x1 (e-PCR)
- UniSTS:190562

AI461280 (e-PCR)
- UniSTS:206557

fc41d04.x1 (e-PCR)
- UniSTS:193776

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of nuclear pore central transport channel	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear transport factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006000.3 → NP_001006000.2 nuclear transport factor 2

See identical proteins and their annotated locations for NP_001006000.2

Status: VALIDATED

Source sequence(s)

BX927175, EH537204

UniProtKB/TrEMBL

A7MCP7, Q1LUT0

Related

ENSDARP00000073506.5, ENSDART00000079050.7

Conserved Domains (1) summary

cd00780
Location:7 → 122

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...