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mogat2 monoacylglycerol O-acyltransferase 2 [ Danio rerio (zebrafish) ]

Gene ID: 450063, updated on 25-Apr-2024

Summary

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Official Symbol
mogat2provided by ZNC
Official Full Name
monoacylglycerol O-acyltransferase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-186
See related
Ensembl:ENSDARG00000019228 AllianceGenome:ZFIN:ZDB-GENE-041010-186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb94h05; zgc:101667
Summary
Predicted to enable 2-acylglycerol O-acyltransferase activity. Acts upstream of or within response to yeast. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Is expressed in intestinal bulb and yolk syncytial layer. Orthologous to several human genes including MOGAT2 (monoacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See mogat2 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (32534814..32610776, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (32590954..32666916, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene UV radiation resistance associated gene Neighboring gene diacylglycerol O-acyltransferase 2 Neighboring gene microtubule-associated protein 6a Neighboring gene uromodulin-like 1 Neighboring gene zinc finger and BTB domain containing 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparative genomics and proteomics of vertebrate diacylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT). Holmes RS. Comp Biochem Physiol Part D Genomics Proteomics, 2010 Mar. PMID 20374941
  2. A novel system to quantify intestinal lipid digestion and transport. Sæle Ø, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Sep. PMID 29778665, Free PMC Article
  3. Evolutionary Origin and Nomenclature of Vertebrate Wnt11-Family Genes. Postlethwait JH, et al. Zebrafish, 2019 Oct. PMID 31295059, Free PMC Article
  4. Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. Wang YC, et al. BMC Syst Biol, 2013 Aug 16. PMID 23947337, Free PMC Article
  5. Peroxisome proliferator-activated receptor gamma is essential for stress adaptation by maintaining lipid homeostasis in female fish. Wang X, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2022 Jul. PMID 35427795

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-acylglycerol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2-acylglycerol O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-methylhexanoyl-CoA C-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables keto acid formate lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in diacylglycerol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to yeast IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
2-acylglycerol O-acyltransferase 2
Names
MGAT2
NP_001006083.2
NP_001313629.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006083.2 → NP_001006083.2  2-acylglycerol O-acyltransferase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR293504, CT573240
    UniProtKB/TrEMBL
    A0A8M1N2V8, F1QSW7
    Related
    ENSDARP00000009175.8, ENSDART00000017436.9

  2. NM_001326700.1 → NP_001313629.1  2-acylglycerol O-acyltransferase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CR293504
    UniProtKB/TrEMBL
    A0A8M1P3L0, F1R0E7
    Related
    ENSDARP00000104851.1, ENSDART00000128888.3
    Conserved Domains (1) summary
    pfam03982
    Location:73 → 368
    DAGAT; Diacylglycerol acyltransferase

RNA

  1. NR_137172.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT573240, EH548819
    Related
    ENSDART00000139808.2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    32534814..32610776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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