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shu shutdown [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45360, updated on 10-May-2024

Summary

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Official Symbol
shuprovided by FlyBase
Official Full Name
shutdownprovided by FlyBase
Primary source
FLYBASE:FBgn0003401
Locus tag
Dmel_CG4735
See related
AllianceGenome:FB:FBgn0003401
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4735; Dmel\CG4735; Shu
Summary
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Involved in oogenesis and piRNA metabolic process. Located in P granule and Yb body. Is expressed in several structures, including germline cell and gonad. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human FKBP6 (FKBP prolyl isomerase family member 6 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See shu in Genome Data Viewer
Location:
60A3-60A3; 2-105 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23841461..23843286, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19728984..19730809, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene long non-coding RNA:CR44805 Neighboring gene uncharacterized protein Neighboring gene Synaptosomal-associated protein 29kDa Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analyses of the Drosophila quit, ovarian tumor and shut down mutants in oocyte differentiation using in situ hybridisation. Tirronen M, et al. Mech Dev, 1993 Jan. PMID 8443104
  2. Functional editing of endogenous genes through rapid selection of cell pools (Rapid generation of endogenously tagged genes in Drosophila ovarian somatic sheath cells). Meng Q, et al. Nucleic Acids Res, 2022 Aug 26. PMID 35639929, Free PMC Article
  3. Acetyltransferase Enok regulates transposon silencing and piRNA cluster transcription. Tsai SY, et al. PLoS Genet, 2021 Feb. PMID 33524038, Free PMC Article
  4. Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries. Pandey RR, et al. PLoS Genet, 2017 Aug. PMID 28827804, Free PMC Article
  5. Requirements for multivalent Yb body assembly in transposon silencing in Drosophila. Hirakata S, et al. EMBO Rep, 2019 Jul. PMID 31267711, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in oogenesis HMP PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in piRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in primary piRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrotransposon silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in secondary piRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Yb body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
shutdown
Names
CG4735-PA
Shut-down
shu-PA
shut down
NP_611837.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23841461..23843286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137993.4 → NP_611837.1  shutdown [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611837.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W1I9
    Related
    FBpp0072146
    Conserved Domains (2) summary
    sd00006
    Location:218 → 257
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:96 → 189
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W1I9.1 Q9W1I9

Gene LinkOut

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