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mllt10 MLLT10 histone lysine methyltransferase DOT1L cofactor [ Danio rerio (zebrafish) ]

Gene ID: 492342, updated on 27-Mar-2024

Summary

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Official Symbol
mllt10provided by ZNC
Official Full Name
MLLT10 histone lysine methyltransferase DOT1L cofactorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041114-176
See related
Ensembl:ENSDARG00000045401 AllianceGenome:ZFIN:ZDB-GENE-041114-176
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92208; id:ibd5120; wu:fe48f12
Summary
Predicted to enable histone binding activity and nucleosome binding activity. Acts upstream of or within canonical Wnt signaling pathway and intestinal epithelial structure maintenance. Predicted to be active in nucleus. Is expressed in brain; hindbrain; intestine; and midbrain. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See mllt10 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
24
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (17142693..17216069)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (17000874..17071645)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, alpha a Neighboring gene SKI/DACH domain containing 1 Neighboring gene COMM domain containing 3 Neighboring gene bmi1 polycomb ring finger oncogene 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. scaRNAs regulate splicing and vertebrate heart development. Patil P, et al. Biochim Biophys Acta, 2015 Aug. PMID 25916634
  2. The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. Mahmoudi T, et al. PLoS Biol, 2010 Nov 16. PMID 21103407, Free PMC Article
  3. Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes. England SJ, et al. Front Cell Dev Biol, 2017. PMID 28271061, Free PMC Article
  4. The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Fellous A, et al. Gene, 2019 Mar 1. PMID 30458291
  5. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intestinal epithelial structure maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein AF-10
Names
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    17142693..17216069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017353906.2 → XP_017209395.2  protein AF-10 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YVP0, F8W451
    Conserved Domains (2) summary
    cd15574
    Location:50 → 97
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:148 → 273
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  2. XM_017353907.2 → XP_017209396.2  protein AF-10 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z452, F8W451
    Conserved Domains (2) summary
    cd15574
    Location:50 → 97
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:148 → 273
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  3. XM_017353909.2 → XP_017209398.2  protein AF-10 isoform X4

    UniProtKB/TrEMBL
    A0A8M6YY56, F8W451
    Conserved Domains (2) summary
    cd15574
    Location:50 → 97
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:148 → 273
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  4. XM_017353908.2 → XP_017209397.2  protein AF-10 isoform X3

    UniProtKB/TrEMBL
    A0A8M6YWA9, F8W451
    Related
    ENSDARP00000123992.1, ENSDART00000149744.2
    Conserved Domains (2) summary
    cd15574
    Location:50 → 97
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:148 → 273
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  5. XM_017353910.2 → XP_017209399.2  protein AF-10 isoform X5

    UniProtKB/TrEMBL
    A0A8M6Z4S2, F8W451
    Related
    ENSDARP00000156939.1, ENSDART00000192259.1
    Conserved Domains (2) summary
    cd15574
    Location:50 → 97
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:148 → 274
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  6. XM_021470301.1 → XP_021325976.1  protein AF-10 isoform X6

    UniProtKB/TrEMBL
    A0A8M9PUD9, F8W451
    Conserved Domains (2) summary
    cd15574
    Location:50 → 97
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:148 → 273
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  7. XM_017353911.2 → XP_017209400.2  protein AF-10 isoform X8

    UniProtKB/TrEMBL
    A0A8M6YVP4, F8W451
    Conserved Domains (2) summary
    cd15574
    Location:50 → 97
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:148 → 269
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  8. XM_009297359.3 → XP_009295634.2  protein AF-10 isoform X7

    UniProtKB/TrEMBL
    A0A8M3AP65, F8W451
    Related
    ENSDARP00000108632.3, ENSDART00000121821.3
    Conserved Domains (2) summary
    cd15574
    Location:50 → 97
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:104 → 231
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  9. XM_017353914.2 → XP_017209403.2  protein AF-10 isoform X12

    UniProtKB/TrEMBL
    A0A8M6YY61
    Conserved Domains (2) summary
    cd15574
    Location:50 → 97
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:148 → 273
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  10. XM_017353912.2 → XP_017209401.2  protein AF-10 isoform X10

    UniProtKB/TrEMBL
    A0A8M6Z457
    Related
    ENSDARP00000144221.1, ENSDART00000177272.2
    Conserved Domains (2) summary
    cd15574
    Location:50 → 97
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:148 → 273
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  11. XM_017353913.2 → XP_017209402.2  protein AF-10 isoform X11

    UniProtKB/TrEMBL
    A0A8M6YWB4
    Conserved Domains (2) summary
    cd15574
    Location:50 → 97
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:148 → 273
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  12. XM_009297362.3 → XP_009295637.2  protein AF-10 isoform X9

    UniProtKB/TrEMBL
    A0A8M3AZ26, F8W451
    Related
    ENSDARP00000124588.1, ENSDART00000149134.3
    Conserved Domains (2) summary
    cd15574
    Location:50 → 97
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:104 → 232
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007308.1: Suppressed sequence

    Description
    NM_001007308.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: MLLT10 (GeneID:8028).
Nucleotide Protein Strain
Heading Accession and Version

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