U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

net1 neuroepithelial cell transforming 1 [ Danio rerio (zebrafish) ]

Gene ID: 493607, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
net1provided by ZNC
Official Full Name
neuroepithelial cell transforming 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-041121-18
See related
Ensembl:ENSDARG00000032765 AllianceGenome:ZFIN:ZDB-GENE-041121-18
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92121; wu:fb13g03; wu:fb25c11
Summary
Enables transcription coactivator activity. Acts upstream of or within dorsal/ventral axis specification; mesendoderm development; and regulation of nodal signaling pathway. Is active in nucleus. Is expressed in axial mesoderm; margin; and shield. Orthologous to human NET1 (neuroepithelial cell transforming 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See net1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (11573552..11603162, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (11574703..11581932, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box containing 13a, tandem duplicate 1 Neighboring gene ankyrin repeat and SOCS box containing 13a, tandem duplicate 2 Neighboring gene microRNA 29b-2 Neighboring gene microRNA 29a-1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A GEF activity-independent function for nuclear Net1 in Nodal signal transduction and mesendoderm formation. Wei S, et al. J Cell Sci, 2017 Sep 15. PMID 28778986
  2. Prepatterning of developmental gene expression by modified histones before zygotic genome activation. Lindeman LC, et al. Dev Cell, 2011 Dec 13. PMID 22137762
  3. The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation. Wei S, et al. Cell Res, 2017 Feb. PMID 27910850, Free PMC Article
  4. Genome-wide RNA Tomography in the zebrafish embryo. Junker JP, et al. Cell, 2014 Oct 23. PMID 25417113
  5. Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. Liu Z, et al. J Biol Chem, 2011 Aug 12. PMID 21669877, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. nuclear Net1 is critical for zebrafish mesendoderm formation and Nodal signal transduction.
    Title: A GEF activity-independent function for nuclear Net1 in Nodal signal transduction and mesendoderm formation.
  2. Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.
    Title: The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase regulator activity TAS
Traceable Author Statement
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mesendoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of nodal signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of nodal signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of nodal signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
neuroepithelial cell-transforming gene 1 protein
Names
neuroepithelial cell transforming gene 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007767.1 → NP_001007768.1  neuroepithelial cell-transforming gene 1 protein

    See identical proteins and their annotated locations for NP_001007768.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085638
    UniProtKB/TrEMBL
    Q5RKM4
    Related
    ENSDARP00000049065.4, ENSDART00000049066.6
    Conserved Domains (3) summary
    smart00325
    Location:123 → 299
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam00169
    Location:332 → 446
    PH; PH domain
    cl17171
    Location:313 → 446
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    11573552..11603162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021475011.1 → XP_021330686.1  neuroepithelial cell-transforming gene 1 protein isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q5V8
    Conserved Domains (2) summary
    smart00325
    Location:177 → 353
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:367 → 500
    PH-like; Pleckstrin homology-like domain

  2. XM_021475012.1 → XP_021330687.1  neuroepithelial cell-transforming gene 1 protein isoform X2

    UniProtKB/TrEMBL
    A0A8M9PH78, Q5RHT9
    Related
    ENSDARP00000011006.6, ENSDART00000002682.8
    Conserved Domains (2) summary
    smart00325
    Location:152 → 328
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:342 → 475
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools