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usp2a ubiquitin specific peptidase 2a [ Danio rerio (zebrafish) ]

Gene ID: 494031, updated on 25-Apr-2024

Summary

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Official Symbol
usp2aprovided by ZNC
Official Full Name
ubiquitin specific peptidase 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041212-59
See related
Ensembl:ENSDARG00000020107 AllianceGenome:ZFIN:ZDB-GENE-041212-59
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92134
Summary
Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Orthologous to human USP2 (ubiquitin specific peptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See usp2a in Genome Data Viewer
Location:
chromosome: 15
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (20900627..20939599, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (20964895..21003867, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene unc-51 like autophagy activating kinase 2 Neighboring gene GTPase IMAP family member 4-like Neighboring gene tubulin folding cofactor E-like a Neighboring gene alpha-2-macroglobulin-like protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Overexpression of ubiquitin-specific protease 2a (USP2a) and nuclear factor erythroid 2-related factor 2 (Nrf2) in human gliomas. Boustani MR, et al. J Neurol Sci, 2016 Apr 15. PMID 27000259
  2. Transcriptional response to cardiac injury in the zebrafish: systematic identification of genes with highly concordant activity across in vivo models. Rodius S, et al. BMC Genomics, 2014 Oct 3. PMID 25280539, Free PMC Article
  3. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High expression of USP2a in brain tissue from primary glioma patients was correlated with poor survival.
    Title: Overexpression of ubiquitin-specific protease 2a (USP2a) and nuclear factor erythroid 2-related factor 2 (Nrf2) in human gliomas.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 2; ubiquitin carboxyl-terminal hydrolase 2a
NP_001008574.2
XP_005157570.1
XP_005157571.1
XP_005157572.1
XP_005157573.1
XP_017206440.1
XP_021337071.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008574.2 → NP_001008574.2  ubiquitin carboxyl-terminal hydrolase 2a

    Status: VALIDATED

    Source sequence(s)
    BX548078
    UniProtKB/TrEMBL
    A0A8M1N3I7, F1R2P1
    Related
    ENSDARP00000119800.1, ENSDART00000134053.4

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    20900627..20939599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157514.4 → XP_005157571.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X1

    See identical proteins and their annotated locations for XP_005157571.1

    UniProtKB/TrEMBL
    A0A8M9QLD6
    Conserved Domains (1) summary
    pfam00443
    Location:230 → 559
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. XM_021481396.1 → XP_021337071.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QLD6
    Conserved Domains (1) summary
    pfam00443
    Location:230 → 559
    UCH; Ubiquitin carboxyl-terminal hydrolase

  3. XM_005157513.4 → XP_005157570.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X1

    See identical proteins and their annotated locations for XP_005157570.1

    UniProtKB/TrEMBL
    A0A8M9QLD6
    Conserved Domains (1) summary
    pfam00443
    Location:230 → 559
    UCH; Ubiquitin carboxyl-terminal hydrolase

  4. XM_005157515.4 → XP_005157572.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B4B5
    Conserved Domains (2) summary
    cd02674
    Location:231 → 559
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:229 → 558
    UCH; Ubiquitin carboxyl-terminal hydrolase

  5. XM_017350951.2 → XP_017206440.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QLD6
    Conserved Domains (1) summary
    pfam00443
    Location:230 → 559
    UCH; Ubiquitin carboxyl-terminal hydrolase

  6. XM_005157516.4 → XP_005157573.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M2B3N0
    Conserved Domains (2) summary
    cd02674
    Location:62 → 391
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:60 → 390
    UCH; Ubiquitin carboxyl-terminal hydrolase
Nucleotide Protein
Heading Accession and Version

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