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tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) [ Danio rerio (zebrafish) ]

Gene ID: 494033, updated on 25-Apr-2024

Summary

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Official Symbol
tfap2cprovided by ZNC
Official Full Name
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)provided by ZNC
Primary source
ZFIN:ZDB-GENE-041212-61
See related
Ensembl:ENSDARG00000040606 AllianceGenome:ZFIN:ZDB-GENE-041212-61
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb48g05; fb49c04; zgc:92088; wu:fb48g05; wu:fb49c04
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within neural crest cell differentiation; olfactory placode development; and otic placode formation. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; epidermis; eye; neurogenic field; and presumptive ectoderm. Orthologous to human TFAP2C (transcription factor AP-2 gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See tfap2c in Genome Data Viewer
Location:
chromosome: 6
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (56141788..56179707)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (56157640..56195515)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene EYA transcriptional coactivator and phosphatase 2 Neighboring gene replication termination factor 2 Neighboring gene glucosaminyl (N-acetyl) transferase family member 7 Neighboring gene uncharacterized protein DDB_G0271670-like Neighboring gene cadherin-22-like Neighboring gene uncharacterized LOC101882673

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of the new vertebrate head by co-option of an ancient chordate skeletal tissue. Jandzik D, et al. Nature, 2015 Feb 26. PMID 25487155
  2. Zebrafish (Danio rerio) endomembrane antiporter similar to a yeast cation/H(+) transporter is required for neural crest development. Manohar M, et al. Biochemistry, 2010 Aug 10. PMID 20578725
  3. Tfap2 transcription factors in zebrafish neural crest development and ectodermal evolution. Hoffman TL, et al. J Exp Zool B Mol Dev Evol, 2007 Sep 15. PMID 17724731
  4. Effects of ethinylestradiol and of an environmentally relevant mixture of xenoestrogens on steroidogenic gene expression and specific transcription factors in zebrafish. Urbatzka R, et al. Environ Pollut, 2012 May. PMID 22318008
  5. Transcriptional control of Rohon-Beard sensory neuron development at the neural plate border. Rossi CC, et al. Dev Dyn, 2009 Apr. PMID 19301392, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ectodermal placode development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within ectodermal placode formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neural crest cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neural crest cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within olfactory placode development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within otic placode formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor AP-2 gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008576.2 → NP_001008576.1  transcription factor AP-2 gamma

    See identical proteins and their annotated locations for NP_001008576.1

    Status: VALIDATED

    Source sequence(s)
    CU468952
    UniProtKB/TrEMBL
    A0A8M1N383, Q5PQZ4
    Related
    ENSDARP00000123798.1, ENSDART00000150219.2
    Conserved Domains (1) summary
    pfam03299
    Location:215 → 415
    TF_AP-2; Transcription factor AP-2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    56141788..56179707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017356481.2 → XP_017211970.1  transcription factor AP-2 gamma isoform X2

    UniProtKB/TrEMBL
    A0A8M6YYQ6

  2. XM_021476853.1 → XP_021332528.1  transcription factor AP-2 gamma isoform X3

    UniProtKB/TrEMBL
    A0A8M9PZP3
    Conserved Domains (1) summary
    pfam03299
    Location:210 → 404
    TF_AP-2; Transcription factor AP-2

  3. XM_021476852.1 → XP_021332527.1  transcription factor AP-2 gamma isoform X1

    UniProtKB/TrEMBL
    A0A8M9PM23
    Conserved Domains (1) summary
    pfam03299
    Location:216 → 410
    TF_AP-2; Transcription factor AP-2
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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