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dpr6 defective proboscis extension response 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 50296, updated on 10-May-2024

Summary

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Official Symbol
dpr6provided by FlyBase
Official Full Name
defective proboscis extension response 6provided by FlyBase
Primary source
FLYBASE:FBgn0040823
Locus tag
Dmel_CG14162
See related
AllianceGenome:FB:FBgn0040823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD13525; CG14162; Dmel\CG14162; Dpr-6; Dpr6
Summary
Involved in synapse organization. Located in neuron projection membrane. Is expressed in larval ventral nerve cord; medulla; and organism. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See dpr6 in Genome Data Viewer
Location:
67D2-67D8; 3-32 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9974651..10139360)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9967751..10132460)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45876 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45877 Neighboring gene variable nurse cells Neighboring gene long non-coding RNA:CR45155 Neighboring gene long non-coding RNA:CR45878 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sting-regulated gene 2 Neighboring gene pseudo Neighboring gene defective proboscis extension response 10 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exercise-induced changes in climbing performance. Watanabe LP, et al. R Soc Open Sci, 2021 Nov. PMID 34804578, Free PMC Article
  2. Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10. Venkatasubramanian L, et al. Elife, 2019 Feb 4. PMID 30714901, Free PMC Article
  3. Affinity requirements for control of synaptic targeting and neuronal cell survival by heterophilic IgSF cell adhesion molecules. Xu S, et al. Cell Rep, 2022 Apr 5. PMID 35385751, Free PMC Article
  4. Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits. Xu S, et al. Neuron, 2018 Dec 19. PMID 30467079, Free PMC Article
  5. Coordination between stochastic and deterministic specification in the Drosophila visual system. Courgeon M, et al. Science, 2019 Oct 18. PMID 31582524, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These studies support an important role for the DIP/Dpr protein interaction network in regulating cell-type-specific connectivity patterns.
    Title: Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in sensory perception of chemical stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse organization IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in neuron projection membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
defective proboscis extension response 6
Names
CG14162-PA
CG14162-PC
CG14162-PD
CG14162-PE
CG14162-PF
defective proboscis response 6
dpr6-PA
dpr6-PC
dpr6-PD
dpr6-PE
dpr6-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9974651..10139360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274746.1 → NP_001261675.1  defective proboscis extension response 6, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261675.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF70
    Conserved Domains (3) summary
    smart00408
    Location:191 → 262
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:184 → 271
    IG_like; Immunoglobulin like
    pfam07686
    Location:79 → 174
    V-set; Immunoglobulin V-set domain

  2. NM_001274745.1 → NP_001261674.1  defective proboscis extension response 6, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261674.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PES4
    Conserved Domains (3) summary
    smart00408
    Location:191 → 262
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:184 → 271
    IG_like; Immunoglobulin like
    pfam07686
    Location:79 → 174
    V-set; Immunoglobulin V-set domain

  3. NM_001300089.2 → NP_001287018.1  defective proboscis extension response 6, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287018.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J8X8
    Conserved Domains (3) summary
    smart00408
    Location:191 → 262
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:184 → 271
    IG_like; Immunoglobulin like
    pfam07686
    Location:79 → 174
    V-set; Immunoglobulin V-set domain

  4. NM_001274744.2 → NP_001261673.1  defective proboscis extension response 6, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261673.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PC40
    Conserved Domains (3) summary
    smart00408
    Location:191 → 262
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:184 → 271
    IG_like; Immunoglobulin like
    cl11960
    Location:79 → 174
    Ig; Immunoglobulin domain

  5. NM_144182.2 → NP_652439.1  defective proboscis extension response 6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652439.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0B9, Q9VT76
    Related
    FBpp0076082
    Conserved Domains (3) summary
    smart00408
    Location:191 → 262
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:184 → 271
    IG_like; Immunoglobulin like
    pfam07686
    Location:79 → 174
    V-set; Immunoglobulin V-set domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PC40 M9PC40
M9PES4 M9PES4
M9PF70 M9PF70
Q9VT76 Q9VT76
X2J8X8 X2J8X8

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