pkz protein kinase containing Z-DNA binding domains [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pkzprovided by ZNC
Official Full Name: protein kinase containing Z-DNA binding domainsprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050301-2
See related: Ensembl:ENSDARG00000052396 AllianceGenome:ZFIN:ZDB-GENE-050301-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:136657
Summary: Enables left-handed Z-DNA binding activity and protein kinase activity. Predicted to act upstream of or within defense response to virus and protein phosphorylation. Predicted to be active in cytosol. Is expressed in several structures, including digestive system; eye; heart; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (50189890..50200119, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (49876647..49886979, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

and Z-DNA and characterize its extremely low B-Z transition activity at 250 mM NaCl. Our results emphasize that the B-DNA-bound form of caZalphaPKZ can be used as molecular ruler to measure the degree of B-Z transition.
Title: NMR elucidation of reduced B-Z transition activity of PKZ protein kinase at high NaCl concentration.
the extra basic residues in the beta-wing of drZalphaPKZ are necessary for the fast B-Z transition activity.
Title: Structural and functional studies of a large winged Z-DNA-binding domain of Danio rerio protein kinase PKZ.
A structural model for the recognition of Z-DNA by Zalpha domains.
Title: Structural basis for Z-DNA binding and stabilization by the zebrafish Z-DNA dependent protein kinase PKZ.
Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.
Title: A truncated Danio rerio PKZ isoform functionally interacts with eIF2α and inhibits protein synthesis.
These results suggest that PKR and PKZ function by distinguishable mechanisms to modulate host responses including protein synthesis inhibition and stress granule formation.
Title: RNA-dependent protein kinase PKR and the Z-DNA binding orthologue PKZ differ in their capacity to mediate initiation factor eIF2α-dependent inhibition of protein synthesis and virus-induced stress granule formation.
a PKR-like kinase from zebrafish
Title: A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables left-handed Z-DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in eiF2alpha phosphorylation in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein kinase containing Z-DNA binding domains

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040376.2 → NP_001035466.1 protein kinase containing Z-DNA binding domains

See identical proteins and their annotated locations for NP_001035466.1

Status: PROVISIONAL

Source sequence(s)

BC131857

UniProtKB/TrEMBL

A2RRU6, F6NJL1, Q5NE12, Q5NE14

Related

ENSDARP00000033668.5, ENSDART00000038391.8

Conserved Domains (3) summary

smart00220
Location:170 → 491

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl02659
Location:4 → 70

z-alpha; Adenosine deaminase z-alpha domain

cl21453
Location:163 → 495

PKc_like; Protein Kinases, catalytic domain