GOLGA7 golgin A7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GOLGA7provided by HGNC
Official Full Name: golgin A7provided by HGNC
Primary source: HGNC:HGNC:24876
See related: Ensembl:ENSG00000147533 MIM:609453; AllianceGenome:HGNC:24876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GCP16; GOLGA7A; HSPC041; GOLGA3AP1
Summary: Involved in Golgi to plasma membrane protein transport; peptidyl-L-cysteine S-palmitoylation; and protein stabilization. Acts upstream of or within Golgi to plasma membrane transport. Located in Golgi membrane and Golgi stack. Is intrinsic component of Golgi membrane. Part of palmitoyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in brain (RPKM 33.3), testis (RPKM 26.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p11.21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (41490396..41510980)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (41764091..41784672)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (41347915..41368499)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry.
Title: The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
results indicate that GCP16 is the acylated membrane protein, associated with GCP170, and possibly involved in vesicular transport from the Golgi to the cell surface
Title: Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170.
Data show that H- and N-Ras are palmitoylated by a human protein palmitoyltransferase encoded by the ZDHHC9 and GCP16 genes.
Title: DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-14408 (e-PCR)
- UniSTS:76474

RH66402 (e-PCR)
- UniSTS:26299

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to plasma membrane protein transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Golgi to plasma membrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-L-cysteine S-palmitoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-L-cysteine S-palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	TAS Traceable Author Statement more info
is_active_in Golgi stack	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi stack	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
part_of palmitoyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of palmitoyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in tertiary granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: golgin subfamily A member 7

Names: Golgi complex-associated protein of 16kDa; golgi autoantigen, golgin subfamily a, 7; golgi complex-associated protein of 16 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002296.2 → NP_001002296.1 golgin subfamily A member 7 isoform a

See identical proteins and their annotated locations for NP_001002296.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, 4 and 5 encode the same isoform (a).

Source sequence(s)

AC009630, AF068291, AF125102, AV650886, BC001227, BC012032, BG939345

Consensus CDS

CCDS34887.1

UniProtKB/Swiss-Prot

D3DSX9, J3KQ24, Q7Z5G4, Q96EQ4, Q9P1S0, Q9Y5U7

UniProtKB/TrEMBL

A0A8Q3WLM5

Related

ENSP00000350378.4, ENST00000357743.9

Conserved Domains (1) summary

pfam10256
Location:12 → 124

Erf4; Golgin subfamily A member 7/ERF4 family
NM_001174124.2 → NP_001167595.1 golgin subfamily A member 7 isoform b

See identical proteins and their annotated locations for NP_001167595.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 2. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AC009630, AK026613, BC001227

Consensus CDS

CCDS55226.1

UniProtKB/TrEMBL

A0A8Q3WLM5

Related

ENSP00000386030.2, ENST00000405786.3

Conserved Domains (1) summary

pfam10256
Location:12 → 123

Erf4; Golgin subfamily A member 7/ERF4 family
NM_001362979.1 → NP_001349908.1 golgin subfamily A member 7 isoform a

Status: VALIDATED

Source sequence(s)

AF068291, AF125102, AV650886, BC001227, BG939345, BI546026

Consensus CDS

CCDS34887.1

UniProtKB/Swiss-Prot

D3DSX9, J3KQ24, Q7Z5G4, Q96EQ4, Q9P1S0, Q9Y5U7

UniProtKB/TrEMBL

A0A8Q3WLM5

Related

ENSP00000429329.1, ENST00000518270.6

Conserved Domains (1) summary

pfam10256
Location:12 → 124

Erf4; Golgin subfamily A member 7/ERF4 family
NM_001362980.2 → NP_001349909.1 golgin subfamily A member 7 isoform a

Status: VALIDATED

Source sequence(s)

AC009630, AF068291, AF125102, AV650886, BC001227, BG939345, BP341683, HY131836

Consensus CDS

CCDS34887.1

UniProtKB/Swiss-Prot

D3DSX9, J3KQ24, Q7Z5G4, Q96EQ4, Q9P1S0, Q9Y5U7

UniProtKB/TrEMBL

A0A8Q3WLM5

Related

ENSP00000511570.1, ENST00000694887.1

Conserved Domains (1) summary

pfam10256
Location:12 → 124

Erf4; Golgin subfamily A member 7/ERF4 family
NM_016099.3 → NP_057183.2 golgin subfamily A member 7 isoform a

See identical proteins and their annotated locations for NP_057183.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2, and encodes the longer isoform (a). Variants 1, 2, 4 and 5 encode the same isoform (a).

Source sequence(s)

AF068291, AF125102, AV650886, BC001227, BC012032, BG939345, BI553491

Consensus CDS

CCDS34887.1

UniProtKB/Swiss-Prot

D3DSX9, J3KQ24, Q7Z5G4, Q96EQ4, Q9P1S0, Q9Y5U7

UniProtKB/TrEMBL

A0A8Q3WLM5

Related

ENSP00000510742.1, ENST00000687203.1

Conserved Domains (1) summary

pfam10256
Location:12 → 124

Erf4; Golgin subfamily A member 7/ERF4 family