U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cdc23 CDC23 cell division cycle 23 [ Mus musculus (house mouse) ]

Gene ID: 52563, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Cdc23provided by MGI
Official Full Name
CDC23 cell division cycle 23provided by MGI
Primary source
MGI:MGI:1098815
See related
Ensembl:ENSMUSG00000024370 AllianceGenome:MGI:1098815
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6030435O18; D18Ertd243e
Summary
Predicted to be involved in several processes, including cellular protein metabolic process; mitotic metaphase plate congression; and regulation of mitotic sister chromatid separation. Predicted to be part of anaphase-promoting complex. Predicted to be active in cytoplasm. Is expressed in 4-cell stage embryo. Orthologous to human CDC23 (cell division cycle 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 24.1), limb E14.5 (RPKM 20.3) and 24 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
18 B1; 18 18.69 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34761401..34784802, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34628348..34651749, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene BRD8 domain containing Neighboring gene bromodomain containing 8 Neighboring gene predicted gene, 41688 Neighboring gene STARR-positive B cell enhancer ABC_E4242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:34784160-34784348 Neighboring gene STARR-positive B cell enhancer ABC_E963 Neighboring gene STARR-seq mESC enhancer starr_44210 Neighboring gene kinesin family member 20A Neighboring gene STARR-seq mESC enhancer starr_44211 Neighboring gene nuclear encoded rRNA 5S 25 Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 3 Neighboring gene predicted gene, 52376 Neighboring gene cell division cycle 25C Neighboring gene ribosomal protein L29, retrotransposed

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cell division cycle 23 is required for mouse oocyte meiotic maturation. Zhou Q, et al. FASEB J, 2020 Jul. PMID 32449168
  2. Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea. Lelli A, et al. J Neurophysiol, 2009 Jun. PMID 19339464, Free PMC Article
  3. APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain. Ferguson CJ, et al. Mol Cell, 2022 Jan 6. PMID 34942119, Free PMC Article
  4. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article
  5. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Homozygous variants in CDC23 cause female infertility characterized by oocyte maturation defects.
    Title: Homozygous variants in CDC23 cause female infertility characterized by oocyte maturation defects.
  2. Cell division cycle 23 is required for mouse oocyte meiotic maturation.
    Title: Cell division cycle 23 is required for mouse oocyte meiotic maturation.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cell division cycle protein 23 homolog
Names
APC8
CDC23 (cell division cycle 23, yeast, homolog)
anaphase-promoting complex subunit 8
cyclosome subunit 8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178347.4 → NP_848124.1  cell division cycle protein 23 homolog

    See identical proteins and their annotated locations for NP_848124.1

    Status: PROVISIONAL

    Source sequence(s)
    AC074335, AC145591
    Consensus CDS
    CCDS29132.1
    UniProtKB/Swiss-Prot
    Q6PD06, Q8BGZ4, Q8C0F1
    UniProtKB/TrEMBL
    A0A0R4J1W7
    Related
    ENSMUSP00000122420.2, ENSMUST00000133181.2
    Conserved Domains (5) summary
    COG0457
    Location:212 → 399
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:367 → 393
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:331 → 364
    TPR_1; Tetratricopeptide repeat
    pfam04049
    Location:28 → 154
    ANAPC8; Anaphase promoting complex subunit 8 / Cdc23
    pfam13414
    Location:367 → 430
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    34761401..34784802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526084.3 → XP_006526147.1  cell division cycle protein 23 homolog isoform X1

    See identical proteins and their annotated locations for XP_006526147.1

    UniProtKB/Swiss-Prot
    Q6PD06, Q8BGZ4, Q8C0F1
    UniProtKB/TrEMBL
    G3X8W7
    Related
    ENSMUSP00000025228.6, ENSMUST00000025228.12
    Conserved Domains (3) summary
    COG2956
    Location:214 → 491
    YciM; Lipopolysaccharide biosynthesis regulator YciM, contains six TPR domains and a predicted metal-binding C-terminal domain [Cell wall/membrane/envelope biogenesis]
    sd00006
    Location:367 → 393
    TPR; TPR repeat [structural motif]
    pfam04049
    Location:45 → 148
    ANAPC8; Anaphase promoting complex subunit 8 / Cdc23
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGZ4.2 GenPept UniProtKB/Swiss-Prot:Q8BGZ4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous