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gtdc1 glycosyltransferase-like domain containing 1 [ Danio rerio (zebrafish) ]

Gene ID: 550132, updated on 12-May-2024

Summary

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Official Symbol
gtdc1provided by ZNC
Official Full Name
glycosyltransferase-like domain containing 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-8
See related
Ensembl:ENSDARG00000020642 AllianceGenome:ZFIN:ZDB-GENE-050417-8
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
QTMAN; zgc:110568
Summary
Acts upstream of or within central nervous system development. Orthologous to human GTDC1 (glycosyltransferase like domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See gtdc1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (25840011..25912999)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (26029804..26101587)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene activin A receptor type 2Aa Neighboring gene zinc finger E-box binding homeobox 2a Neighboring gene Rho GTPase activating protein 15 Neighboring gene arginine and glutamate rich 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Personalized genome sequencing coupled with iPSC technology identifies GTDC1 as a gene involved in neurodevelopmental disorders. Aksoy I, et al. Hum Mol Genet, 2017 Jan 15. PMID 28365779
  2. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-queuosine(34) beta-mannosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA modification ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tRNA-queuosine alpha-mannosyltransferase; glycosyltransferase-like domain-containing protein 1
NP_001017560.1
XP_005167614.1
XP_017213160.1
XP_021334324.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017560.1 → NP_001017560.1  tRNA-queuosine alpha-mannosyltransferase

    See identical proteins and their annotated locations for NP_001017560.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092932
    UniProtKB/Swiss-Prot
    Q568B7
    Related
    ENSDARP00000016818.5, ENSDART00000024572.7
    Conserved Domains (4) summary
    cd01635
    Location:172 → 354
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    COG0438
    Location:255 → 421
    RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    pfam12038
    Location:2 → 164
    DUF3524; Domain of unknown function (DUF3524)
    cl10013
    Location:303 → 421
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    25840011..25912999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167557.4 → XP_005167614.1  glycosyltransferase-like domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z8E3
    Conserved Domains (4) summary
    cd01635
    Location:172 → 353
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    COG0438
    Location:254 → 420
    RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    pfam12038
    Location:2 → 164
    DUF3524; Domain of unknown function (DUF3524)
    cl10013
    Location:302 → 420
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

  2. XM_021478649.1 → XP_021334324.1  glycosyltransferase-like domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B0S8J7, Q568B7
    UniProtKB/TrEMBL
    A0A8M9QAN7
    Related
    ENSDARP00000109130.3, ENSDART00000127135.3
    Conserved Domains (2) summary
    cd01635
    Location:167 → 368
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
    pfam12038
    Location:2 → 164
    DUF3524; Domain of unknown function (DUF3524)

  3. XM_017357671.2 → XP_017213160.1  glycosyltransferase-like domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z8E3
    Conserved Domains (4) summary
    cd01635
    Location:172 → 353
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    COG0438
    Location:254 → 420
    RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    pfam12038
    Location:2 → 164
    DUF3524; Domain of unknown function (DUF3524)
    cl10013
    Location:302 → 420
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q568B7.2 GenPept UniProtKB/Swiss-Prot:Q568B7

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