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tnni2b.1 troponin I type 2b (skeletal, fast), tandem duplicate 1 [ Danio rerio (zebrafish) ]

Gene ID: 550249, updated on 25-Apr-2024

Summary

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Official Symbol
tnni2b.1provided by ZNC
Official Full Name
troponin I type 2b (skeletal, fast), tandem duplicate 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-49
See related
Ensembl:ENSDARG00000035958 AllianceGenome:ZFIN:ZDB-GENE-050417-49
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tropI-2a; zgc:110715
Summary
Predicted to be involved in cardiac muscle contraction and skeletal muscle contraction. Predicted to be part of troponin complex. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; distal arthrogryposis type 2B1; and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including TNNI2 (troponin I2, fast skeletal type). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See tnni2b.1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (39401388..39406765)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (39130371..39135748)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 member B1 Neighboring gene troponin I type 2b (skeletal, fast), tandem duplicate 2 Neighboring gene lymphocyte specific protein 1 b Neighboring gene uncharacterized LOC560010 Neighboring gene troponin T type 3b (skeletal, fast)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Functional Divergence in Teleost Cardiac Troponin Paralogs Guides Variation in the Interaction of TnI Switch Region with TnC. Genge CE, et al. Genome Biol Evol, 2016 Apr 11. PMID 26979795, Free PMC Article
  2. Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos. Hausen J, et al. Environ Sci Pollut Res Int, 2018 Feb. PMID 28391457
  3. A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis. Seda M, et al. Sci Rep, 2023 Apr 26. PMID 37100808, Free PMC Article
  4. "Young at heart": Regenerative potential linked to immature cardiac phenotypes. Gomes RS, et al. J Mol Cell Cardiol, 2016 Mar. PMID 26827899, Free PMC Article
  5. An update on MyoD evolution in teleosts and a proposed consensus nomenclature to accommodate the tetraploidization of different vertebrate genomes. Macqueen DJ, et al. PLoS One, 2008 Feb 6. PMID 18253507, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of troponin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
troponin I type 2b (skeletal, fast), tandem duplicate 1
Names
troponin I, skeletal, fast 2b.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017587.2 → NP_001017587.2  troponin I type 2b (skeletal, fast), tandem duplicate 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT030188, EH474473
    UniProtKB/TrEMBL
    A0A8M1NJH6, F1QCC0, Q567W1
    Related
    ENSDARP00000023228.9, ENSDART00000025852.10
    Conserved Domains (1) summary
    pfam00992
    Location:11 → 137
    Troponin; Troponin

  2. NM_001136492.2 → NP_001129964.1  troponin I type 2b (skeletal, fast), tandem duplicate 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT030188, CT600646, EH477096
    UniProtKB/TrEMBL
    A0A8M1NJH6, F1QCC0, Q567W1
    Related
    ENSDARP00000120317.1, ENSDART00000144750.3
    Conserved Domains (1) summary
    pfam00992
    Location:11 → 137
    Troponin; Troponin

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    39401388..39406765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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