cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cox10provided by ZNC
Official Full Name: cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10provided by ZNC
Primary source: ZFIN:ZDB-GENE-041111-239
See related: Ensembl:ENSDARG00000034309 AllianceGenome:ZFIN:ZDB-GENE-041111-239
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7145568; im:7157205; wu:fb18a03
Summary: Predicted to enable farnesyltranstransferase activity. Predicted to be involved in cellular respiration and heme biosynthetic process. Predicted to act upstream of or within heme O biosynthetic process. Predicted to be located in mitochondrial membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (36891483..36960525)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (36716741..36785783)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi87g07.x1 (e-PCR)
- UniSTS:198147

fb18a03.x1 (e-PCR)
- UniSTS:202998

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ADP dimethylallyltransferase activity	IEA Inferred from Electronic Annotation more info
enables ATP dimethylallyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protoheme IX farnesyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protoheme IX farnesyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring alkyl or aryl (other than methyl) groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heme A biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heme biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protoheme IX farnesyltransferase, mitochondrial

Names: COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase; cytochrome c oxidase assembly homolog 10

NP_001159731.1

EC 2.5.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166259.1 → NP_001159731.1 protoheme IX farnesyltransferase, mitochondrial

Status: VALIDATED

Source sequence(s)

BC124463, CR749163

UniProtKB/TrEMBL

A0A8M1NVI9, F1QL30, Q08C12

Related

ENSDARP00000048926.6, ENSDART00000048927.7

Conserved Domains (1) summary

cd13957
Location:157 → 412

PT_UbiA_Cox10; Protoheme IX farnesyltransferase