uqcrb ubiquinol-cytochrome c reductase binding protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: uqcrbprovided by ZNC
Official Full Name: ubiquinol-cytochrome c reductase binding proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-542
See related: Ensembl:ENSDARG00000011146 AllianceGenome:ZFIN:ZDB-GENE-050522-542
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:6900881; zgc:109893
Summary: Acts upstream of or within angiogenesis. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be part of mitochondrial respiratory chain complex III. Is expressed in several structures, including adaxial cell; alar plate midbrain region; digestive system; optic tectum; and pronephric duct. Human ortholog(s) of this gene implicated in inherited metabolic disorder and mitochondrial complex III deficiency nuclear type 3. Orthologous to human UQCRB (ubiquinol-cytochrome c reductase binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (44049500..44055026, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (44453931..44459431, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish angiogenesis is inhibited by UQCRB knockdown.
Title: Functional inhibition of UQCRB suppresses angiogenesis in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial electron transport, ubiquinol to cytochrome c	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
part_of mitochondrial respiratory chain complex III	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex III	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in respirasome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome b-c1 complex subunit 7

NP_001019613.1

EC 7.1.1.8

XP_009292718.1

EC 7.1.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.