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dync1li1 dynein, cytoplasmic 1, light intermediate chain 1 [ Danio rerio (zebrafish) ]

Gene ID: 556103, updated on 27-Mar-2024

Summary

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Official Symbol
dync1li1provided by ZNC
Official Full Name
dynein, cytoplasmic 1, light intermediate chain 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4108
See related
Ensembl:ENSDARG00000098317 AllianceGenome:ZFIN:ZDB-GENE-030131-4108
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dncli2; fc73a07; wu:fc73a07; si:dkey-63j1.8
Summary
Predicted to enable dynein heavy chain binding activity. Acts upstream of or within regulation of mitotic cell cycle, embryonic and regulation of mitotic spindle organization. Predicted to be located in cytoplasm and microtubule. Predicted to be part of cytoplasmic dynein complex. Predicted to colocalize with centrosome. Is expressed in liver. Orthologous to human DYNC1LI1 (dynein cytoplasmic 1 light intermediate chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See dync1li1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (18989911..19026046, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (19416958..19453089, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 7 Neighboring gene CKLF-like MARVEL transmembrane domain containing 8a Neighboring gene copine IVb Neighboring gene uncharacterized LOC110438147 Neighboring gene mitochondrial ribosomal protein L3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Knockout of DLIC1 leads to retinal cone degeneration via disturbing Rab8 transport in zebrafish. Zhang J, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Apr. PMID 36682603
  2. The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation. Mahale S, et al. Sci Rep, 2016 Dec 23. PMID 28003657, Free PMC Article
  3. Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division. Zhao X, et al. Sci Adv, 2021 Jun. PMID 34117063, Free PMC Article
  4. JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes. Drerup CM, et al. PLoS Genet, 2013. PMID 23468645, Free PMC Article
  5. Crtap and p3h1 knock out zebrafish support defective collagen chaperoning as the cause of their osteogenesis imperfecta phenotype. Tonelli F, et al. Matrix Biol, 2020 Aug. PMID 32173581

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockout of DLIC1 leads to retinal cone degeneration via disturbing Rab8 transport in zebrafish.
    Title: Knockout of DLIC1 leads to retinal cone degeneration via disturbing Rab8 transport in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of mitotic cell cycle, embryonic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytoplasmic dynein 1 light intermediate chain 1
Names
dynein, cytoplasmic, light intermediate chain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102428.1 → NP_001095898.1  cytoplasmic dynein 1 light intermediate chain 1

    See identical proteins and their annotated locations for NP_001095898.1

    Status: PROVISIONAL

    Source sequence(s)
    FP085415
    UniProtKB/TrEMBL
    A3KPZ3, Q1LUM9
    Related
    ENSDARP00000138705.1, ENSDART00000167951.2
    Conserved Domains (3) summary
    pfam05783
    Location:29 → 495
    DLIC; Dynein light intermediate chain (DLIC)
    pfam13238
    Location:56 → 178
    AAA_18; AAA domain
    cl21455
    Location:217 → 287
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    18989911..19026046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159514.3 → XP_005159571.1  cytoplasmic dynein 1 light intermediate chain 1 isoform X1

    UniProtKB/TrEMBL
    A0A0R4ICI6, A0A8M2B6A0
    Related
    ENSDARP00000132385.1, ENSDART00000163359.2
    Conserved Domains (3) summary
    pfam05783
    Location:29 → 485
    DLIC; Dynein light intermediate chain (DLIC)
    pfam13238
    Location:56 → 178
    AAA_18; AAA domain
    cl21455
    Location:217 → 287
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_009294161.3 → XP_009292436.1  cytoplasmic dynein 1 light intermediate chain 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3ASH7
    Conserved Domains (3) summary
    pfam05783
    Location:29 → 452
    DLIC; Dynein light intermediate chain (DLIC)
    pfam13238
    Location:56 → 178
    AAA_18; AAA domain
    cl21455
    Location:217 → 287
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_009294160.3 → XP_009292435.1  cytoplasmic dynein 1 light intermediate chain 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AVG4
    Conserved Domains (3) summary
    pfam05783
    Location:29 → 462
    DLIC; Dynein light intermediate chain (DLIC)
    pfam13238
    Location:56 → 178
    AAA_18; AAA domain
    cl21455
    Location:217 → 287
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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