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nub1 negative regulator of ubiquitin-like proteins 1 [ Danio rerio (zebrafish) ]

Gene ID: 557021, updated on 27-Mar-2024

Summary

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Official Symbol
nub1provided by ZNC
Official Full Name
negative regulator of ubiquitin-like proteins 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-080212-11
See related
Ensembl:ENSDARG00000061417 AllianceGenome:ZFIN:ZDB-GENE-080212-11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:171563
Summary
Predicted to be involved in regulation of ubiquitin-dependent protein catabolic process. Orthologous to human NUB1 (negative regulator of ubiquitin like proteins 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See nub1 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (41272958..41303239)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (41409640..41439804)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene activin A receptor type 2Ba Neighboring gene xylulokinase homolog (H. influenzae) Neighboring gene crystallin, gamma N2 Neighboring gene Ras homolog, mTORC1 binding

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mutations of RNF213 are responsible for sporadic cerebral cavernous malformation and lead to a mulberry-like cluster in zebrafish. Lin J, et al. J Cereb Blood Flow Metab, 2021 Jun. PMID 32248732, Free PMC Article
  2. Telencephalon transcriptome analysis of chronically stressed adult zebrafish. Huang V, et al. Sci Rep, 2019 Feb 4. PMID 30718621, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in regulation of ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
NEDD8 ultimate buster 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113580.1 → NP_001107052.1  NEDD8 ultimate buster 1

    See identical proteins and their annotated locations for NP_001107052.1

    Status: PROVISIONAL

    Source sequence(s)
    BC154454
    UniProtKB/TrEMBL
    A8WFT9
    Conserved Domains (4) summary
    cd01769
    Location:108 → 158
    UBL; Ubiquitin-like domain of UBL
    cd14291
    Location:369 → 404
    UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cd14292
    Location:427 → 461
    UBA2_NUB1; UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cl21463
    Location:470 → 505
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    41272958..41303239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170646.4 → XP_005170703.1  NEDD8 ultimate buster 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BHY2
    Conserved Domains (4) summary
    cd01769
    Location:100 → 157
    UBL; Ubiquitin-like domain of UBL
    cd14291
    Location:369 → 404
    UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cd14292
    Location:427 → 461
    UBA2_NUB1; UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cl21463
    Location:474 → 508
    UBA_like_SF; UBA domain-like superfamily

  2. XM_009297673.3 → XP_009295948.1  NEDD8 ultimate buster 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AW93
    Related
    ENSDARP00000128904.1, ENSDART00000155151.2
    Conserved Domains (4) summary
    cd01769
    Location:100 → 157
    UBL; Ubiquitin-like domain of UBL
    cd14291
    Location:369 → 404
    UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cd14292
    Location:427 → 461
    UBA2_NUB1; UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cl21463
    Location:474 → 508
    UBA_like_SF; UBA domain-like superfamily
Nucleotide Protein Strain
Heading Accession and Version

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