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tp53bp1 tumor protein p53 binding protein, 1 [ Danio rerio (zebrafish) ]

Gene ID: 557086, updated on 27-Mar-2024

Summary

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Official Symbol
tp53bp1provided by ZNC
Official Full Name
tumor protein p53 binding protein, 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3695
See related
Ensembl:ENSDARG00000079000 AllianceGenome:ZFIN:ZDB-GENE-030131-3695
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fc50a09; wu:fj67d04; zgc:158452
Summary
Predicted to enable histone binding activity. Predicted to be involved in DNA damage checkpoint signaling and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See tp53bp1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
31
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (52885566..52933190)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (52610506..52662065)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene diphosphoinositol pentakisphosphate kinase 1a Neighboring gene microtubule-associated protein 1Aa Neighboring gene uncharacterized LOC108190716 Neighboring gene tubulin gamma complex component 4 Neighboring gene CDKN2A interacting protein Neighboring gene cocaine- and amphetamine-regulated transcript 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Nucleoporin 62-Like Protein is Required for the Development of Pharyngeal Arches through Regulation of Wnt/β-Catenin Signaling and Apoptotic Homeostasis in Zebrafish. Yang X, et al. Cells, 2019 Sep 5. PMID 31492028, Free PMC Article
  2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC158452

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TP53-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080170.1 → NP_001073639.1  TP53-binding protein 1

    See identical proteins and their annotated locations for NP_001073639.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129236
    UniProtKB/TrEMBL
    A1L1W2
    Related
    ENSDARP00000101125.2, ENSDART00000109973.5
    Conserved Domains (2) summary
    smart00292
    Location:1514 → 1579
    BRCT; breast cancer carboxy-terminal domain
    cl02573
    Location:1248 → 1368
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    52885566..52933190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017356867.2 → XP_017212356.1  TP53-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z753

  2. XM_017356866.1 → XP_017212355.1  TP53-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z753

  3. XM_017356868.1 → XP_017212357.1  TP53-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M6YZZ7

  4. XM_017356871.2 → XP_017212360.1  TP53-binding protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8M6Z7P8

  5. XM_017356870.2 → XP_017212359.1  TP53-binding protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8M6Z7P8

  6. XM_017356869.2 → XP_017212358.1  TP53-binding protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M6Z1I8

  7. XM_021477547.1 → XP_021333222.1  TP53-binding protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M9PNZ2
    Conserved Domains (3) summary
    cl00038
    Location:1437 → 1518
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cl02573
    Location:1175 → 1295
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cl26464
    Location:164 → 475
    Atrophin-1; Atrophin-1 family
Nucleotide Protein
Heading Accession and Version

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