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nob1 NIN1 (RPN12) binding protein 1 homolog [ Danio rerio (zebrafish) ]

Gene ID: 557254, updated on 27-Mar-2024

Summary

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Official Symbol
nob1provided by ZNC
Official Full Name
NIN1 (RPN12) binding protein 1 homologprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3112
See related
Ensembl:ENSDARG00000016080 AllianceGenome:ZFIN:ZDB-GENE-030131-3112
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Nob1p; fc27e05; wu:fc27e05; si:ch73-167i17.3
Summary
Predicted to enable endoribonuclease activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to act upstream of or within cleavage involved in rRNA processing and ribosomal small subunit biogenesis. Predicted to be located in nucleus. Predicted to be part of preribosome, small subunit precursor. Orthologous to human NOB1 (NIN1 (RPN12) binding protein 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See nob1 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (5860217..5875241, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (5245302..5260449, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene NIP7 nucleolar pre-rRNA processing protein Neighboring gene component of oligomeric golgi complex 8 Neighboring gene WD repeat domain 59 Neighboring gene golgi glycoprotein 1b Neighboring gene zinc finger homeobox 3a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ribosomal small subunit biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, small subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein NOB1
Names
nin one binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    5860217..5875241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467739.1 → XP_021323414.1  RNA-binding protein NOB1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PFN4
    Conserved Domains (2) summary
    cd09876
    Location:9 → 112
    PIN_Nob1; PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein Ta0041-like homologs
    pfam08772
    Location:244 → 316
    NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like

  2. XM_678662.9 → XP_683754.2  RNA-binding protein NOB1 isoform X1

    UniProtKB/TrEMBL
    A0A8N7TEG7, I3ISV3
    Related
    ENSDARP00000125998.2, ENSDART00000151727.2
    Conserved Domains (3) summary
    cd09876
    Location:9 → 112
    PIN_Nob1; PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein Ta0041-like homologs
    pfam15017
    Location:140 → 249
    AF1Q; Drug resistance and apoptosis regulator
    pfam08772
    Location:289 → 361
    NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like

  3. XM_009293382.2 → XP_009291657.1  RNA-binding protein NOB1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AUP7
    Conserved Domains (3) summary
    pfam15017
    Location:69 → 178
    AF1Q; Drug resistance and apoptosis regulator
    pfam08772
    Location:218 → 290
    NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like
    cl14812
    Location:178 → 253
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
Nucleotide Protein Strain
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