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polr3b polymerase (RNA) III (DNA directed) polypeptide B [ Danio rerio (zebrafish) ]

Gene ID: 562329, updated on 12-May-2024

Summary

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Official Symbol
polr3bprovided by ZNC
Official Full Name
polymerase (RNA) III (DNA directed) polypeptide Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2887
See related
Ensembl:ENSDARG00000062915 AllianceGenome:ZFIN:ZDB-GENE-030131-2887
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fc20h06; si:dkey-103i16.3
Summary
Predicted to enable several functions, including DNA binding activity; metal ion binding activity; and ribonucleoside binding activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Acts upstream of or within digestive tract development; exocrine pancreas development; and tRNA transcription. Predicted to be part of RNA polymerase III complex. Is expressed in intestine; liver; nervous system; and retina. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism. Orthologous to human POLR3B (RNA polymerase III subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See polr3b in Genome Data Viewer
Location:
chromosome: 18
Exon count:
28
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (15381750..15420303, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (15413238..15451784, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene RIC8 guanine nucleotide exchange factor B Neighboring gene regulatory factor X, 4 Neighboring gene uncharacterized LOC110438087 Neighboring gene uncharacterized LOC108179963

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Intestinal growth and differentiation in zebrafish. Wallace KN, et al. Mech Dev, 2005 Feb. PMID 15652704
  2. Mutations affecting development of zebrafish digestive organs. Pack M, et al. Development, 1996 Dec. PMID 9007252
  3. Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development. Yee NS, et al. PLoS Biol, 2007 Nov. PMID 18044988, Free PMC Article
  4. A genetic screen for mutations affecting embryogenesis in zebrafish. Driever W, et al. Development, 1996 Dec. PMID 9007227
  5. Exocrine pancreas development in zebrafish. Yee NS, et al. Dev Biol, 2005 Aug 1. PMID 15963491

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within exocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tRNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase III subunit RPC2
Names
slim jim
slj
XP_021323450.1
XP_690811.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    15381750..15420303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467775.1 → XP_021323450.1  DNA-directed RNA polymerase III subunit RPC2

    UniProtKB/TrEMBL
    A0A8N7T7P2, F1QQA2
    Related
    ENSDARP00000085899.5, ENSDART00000091466.7
    Conserved Domains (3) summary
    cd00653
    Location:37 → 1124
    RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
    pfam04566
    Location:536 → 597
    RNA_pol_Rpb2_4; RNA polymerase Rpb2, domain 4
    pfam04567
    Location:618 → 658
    RNA_pol_Rpb2_5; RNA polymerase Rpb2, domain 5

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395015.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    220786..259157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_685719.7 → XP_690811.2  DNA-directed RNA polymerase III subunit RPC2

    UniProtKB/TrEMBL
    A0A8N7T7P2, F1QQA2
    Conserved Domains (3) summary
    cd00653
    Location:37 → 1124
    RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
    pfam04566
    Location:536 → 597
    RNA_pol_Rpb2_4; RNA polymerase Rpb2, domain 4
    pfam04567
    Location:618 → 658
    RNA_pol_Rpb2_5; RNA polymerase Rpb2, domain 5
Nucleotide Protein Strain
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