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med13b mediator complex subunit 13b [ Danio rerio (zebrafish) ]

Gene ID: 564707, updated on 27-Mar-2024

Summary

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Official Symbol
med13bprovided by ZNC
Official Full Name
mediator complex subunit 13bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3529
See related
Ensembl:ENSDARG00000003910 AllianceGenome:ZFIN:ZDB-GENE-030131-3529
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
med13; fc43h07; fc43h08; wu:fb66c06; wu:fc43h07; wu:fc43h08; zgc:153454
Summary
Predicted to enable transcription coregulator activity. Acts upstream of or within neural crest cell migration. Predicted to be located in nucleus. Predicted to be part of mediator complex. Is expressed in blastomere; nervous system; pectoral fin; and pectoral fin bud. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human MED13 (mediator complex subunit 13). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See med13b in Genome Data Viewer
Location:
chromosome: 15
Exon count:
30
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (20060643..20125164, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (20124911..20189432, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene zgc:112083 Neighboring gene activator of transcription and developmental regulator AUTS2 b Neighboring gene exocyst complex component 3-like 2b Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14Ab

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Impaired development of neural-crest cell-derived organs and intellectual disability caused by MED13L haploinsufficiency. Utami KH, et al. Hum Mutat, 2014 Nov. PMID 25137640
  2. auts2 Features and Expression Are Highly Conserved during Evolution Despite Different Evolutionary Fates Following Whole Genome Duplication. Merdrignac C, et al. Cells, 2022 Aug 30. PMID 36078102, Free PMC Article
  3. Transcriptional Complexity and Distinct Expression Patterns of auts2 Paralogs in Danio rerio. Kondrychyn I, et al. G3 (Bethesda), 2017 Aug 7. PMID 28626003, Free PMC Article
  4. MicroRNA profile of immune response in gills of zebrafish (Danio rerio) upon Staphylococcus aureus infection. Zhang QL, et al. Fish Shellfish Immunol, 2019 Apr. PMID 30677514
  5. Dynamic transcriptomic profiles of zebrafish gills in response to zinc supplementation. Zheng D, et al. BMC Genomics, 2010 Oct 11. PMID 20937081, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • KIAA0593

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 13-like
Names
mediator complex subunit 13
thyroid hormone receptor-associated protein complex 240 kDa component-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083838.1 → NP_001077307.1  mediator of RNA polymerase II transcription subunit 13-like

    See identical proteins and their annotated locations for NP_001077307.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129032
    UniProtKB/Swiss-Prot
    A2VCZ5
    Related
    ENSDARP00000126727.1, ENSDART00000152355.2
    Conserved Domains (2) summary
    pfam06333
    Location:1584 → 2089
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam11597
    Location:14 → 383
    Med13_N; Mediator complex subunit 13 N-terminal

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    20060643..20125164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2VCZ5.1 GenPept UniProtKB/Swiss-Prot:A2VCZ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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