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larp6b La ribonucleoprotein 6, translational regulator b [ Danio rerio (zebrafish) ]

Gene ID: 565767, updated on 11-Apr-2024

Summary

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Official Symbol
larp6bprovided by ZNC
Official Full Name
La ribonucleoprotein 6, translational regulator bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041008-244
See related
Ensembl:ENSDARG00000003968 AllianceGenome:ZFIN:ZDB-GENE-041008-244
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7142825; wu:fa55b04; zgc:162969
Summary
Predicted to enable mRNA binding activity. Predicted to act upstream of or within RNA processing. Predicted to be part of polysome. Predicted to be active in nucleus. Orthologous to human LARP6 (La ribonucleoprotein 6, translational regulator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See larp6b in Genome Data Viewer
Location:
chromosome: 11
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (6446235..6452467, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (6436396..6442628, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene vimentin-type intermediate filament-associated coiled-coil protein-like Neighboring gene NADH:ubiquinone oxidoreductase subunit A11 Neighboring gene vimentin type intermediate filament associated coiled-coil protein Neighboring gene growth arrest and DNA-damage-inducible, beta a Neighboring gene uncharacterized LOC110440089

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Recombinant expression and purification of the RNA-binding LARP6 proteins from fish genetic model organisms. Castro JM, et al. Protein Expr Purif, 2017 Jun. PMID 28400296, Free PMC Article
  2. Maternal Larp6 controls oocyte development, chorion formation and elevation. Hau HTA, et al. Development, 2020 Feb 26. PMID 32054660, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Larp6 proteins are required for normal oocyte development, chorion formation and egg activation
    Title: Maternal Larp6 controls oocyte development, chorion formation and elevation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
la-related protein 6b
Names
La ribonucleoprotein domain family, member 6
La ribonucleoprotein domain family, member 6b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089408.1 → NP_001082877.1  la-related protein 6b

    See identical proteins and their annotated locations for NP_001082877.1

    Status: PROVISIONAL

    Source sequence(s)
    BC134173
    UniProtKB/TrEMBL
    A3KP60
    Related
    ENSDARP00000019822.6, ENSDART00000004483.8
    Conserved Domains (3) summary
    cd08033
    Location:62 → 138
    LARP_6; La RNA-binding domain of La-related protein 6
    pfam12901
    Location:445 → 459
    SUZ-C; SUZ-C motif
    cl17169
    Location:153 → 261
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    6446235..6452467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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