U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

fes FES proto-oncogene, tyrosine kinase [ Danio rerio (zebrafish) ]

Gene ID: 566739, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
fesprovided by ZNC
Official Full Name
FES proto-oncogene, tyrosine kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-100812-10
See related
Ensembl:ENSDARG00000011449 AllianceGenome:ZFIN:ZDB-GENE-100812-10
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including innate immune response; regulation of mast cell degranulation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See fes in Genome Data Viewer
Location:
chromosome: 7
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (14211148..14266254)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (13965859..14020788)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene stereocilin-like Neighboring gene stereocilin-like Neighboring gene furin (paired basic amino acid cleaving enzyme) a Neighboring gene Rh family, C glycoprotein a Neighboring gene uncharacterized LOC108190637

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nodal signaling range is regulated by proprotein convertase-mediated maturation. Tessadori F, et al. Dev Cell, 2015 Mar 9. PMID 25684355
  2. Irf8 regulates the progression of myeloproliferative neoplasm-like syndrome via Mertk signaling in zebrafish. Zhao F, et al. Leukemia, 2018 Jan. PMID 28626217
  3. Conservation and early expression of zebrafish tyrosine kinases support the utility of zebrafish as a model for tyrosine kinase biology. Challa AK, et al. Zebrafish, 2013 Sep. PMID 23234507, Free PMC Article
  4. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article
  5. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tyrosine-protein kinase Fes/Fps
Names
feline sarcoma oncogene
NP_001186798.1
XP_005166438.1
XP_005166440.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199869.1 → NP_001186798.1  tyrosine-protein kinase Fes/Fps

    Status: VALIDATED

    Source sequence(s)
    CU467822, CU469517
    UniProtKB/TrEMBL
    A0A2R8Q7T0, A0A8M1NXI9
    Related
    ENSDARP00000147268.1, ENSDART00000180985.1
    Conserved Domains (4) summary
    cd07685
    Location:7 → 243
    F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
    cd10361
    Location:457 → 541
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:568 → 822
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:565 → 821
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    14211148..14266254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166381.4 → XP_005166438.1  tyrosine-protein kinase Fes/Fps isoform X1

    UniProtKB/TrEMBL
    A0A8M2BDT6
    Conserved Domains (4) summary
    cd07685
    Location:7 → 243
    F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
    cd10361
    Location:466 → 550
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    pfam07714
    Location:574 → 830
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:577 → 831
    PKc_like; Protein Kinases, catalytic domain

  2. XM_005166383.4 → XP_005166440.1  tyrosine-protein kinase Fes/Fps isoform X2

    UniProtKB/TrEMBL
    A0A8M2BDW8, F8W425
    Related
    ENSDARP00000124270.1, ENSDART00000149938.4
    Conserved Domains (4) summary
    cd07685
    Location:7 → 243
    F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
    cd10361
    Location:457 → 541
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:568 → 822
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:565 → 821
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.