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Rnase4 ribonuclease A family member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 56759, updated on 13-Apr-2024

Summary

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Official Symbol
Rnase4provided by RGD
Official Full Name
ribonuclease A family member 4provided by RGD
Primary source
RGD:61823
See related
Ensembl:ENSRNOG00000025625 AllianceGenome:RGD:61823
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rab1
Summary
Predicted to enable ribonuclease activity. Predicted to be involved in RNA phosphodiester bond hydrolysis. Predicted to act upstream of or within cellular response to starvation. Predicted to be located in extracellular region. Predicted to be part of proton-transporting V-type ATPase, V1 domain. Predicted to be active in extracellular space. Orthologous to human RNASE4 (ribonuclease A family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 2203.4), Lung (RPKM 126.0) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
15p14
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (26786287..26803634)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24312765..24330112)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28018040..28035395)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene transfer RNA tyrosine (anticodon GUA) 4 Neighboring gene transfer RNA proline (anticodon UGG) 6 Neighboring gene angiogenin Neighboring gene ribonuclease, RNase A family, 1-like 1 Neighboring gene epididymal protein 3B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ribonucleases from rat and bovine liver: purification, specificity and structural characterization. Zhao W, et al. Biochim Biophys Acta, 1998 Apr 23. PMID 9602056
  2. Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity. Shapiro R, et al. Biochemistry, 1986 Nov 18. PMID 3467790
  3. Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Boj SF, et al. Cell, 2012 Dec 21. PMID 23260145
  4. Comparative genomic analysis of eutherian ribonuclease A genes. Premzl M. Mol Genet Genomics, 2014 Apr. PMID 24337645
  5. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA nuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA nuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
  
involved_in antibacterial humoral response ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of proton-transporting V-type ATPase, V1 domain IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribonuclease 4
Names
RL3
RNase 4
ribonuclease A b1
ribonuclease, RNase A family 4
NP_064467.1
XP_063130661.1
XP_063130662.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020082.2 → NP_064467.1  ribonuclease 4 precursor

    See identical proteins and their annotated locations for NP_064467.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070953
    UniProtKB/Swiss-Prot
    O55004
    UniProtKB/TrEMBL
    W0UVG1
    Related
    ENSRNOP00000043003.2, ENSRNOT00000041495.5
    Conserved Domains (1) summary
    smart00092
    Location:29 → 147
    RNAse_Pc; Pancreatic ribonuclease

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    26786287..26803634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274591.1 → XP_063130661.1  ribonuclease 4 isoform X1

    UniProtKB/Swiss-Prot
    O55004
    UniProtKB/TrEMBL
    W0UVG1

  2. XM_063274592.1 → XP_063130662.1  ribonuclease 4 isoform X1

    UniProtKB/Swiss-Prot
    O55004
    UniProtKB/TrEMBL
    W0UVG1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55004.1 GenPept UniProtKB/Swiss-Prot:O55004

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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