oc90 otoconin 90 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: oc90provided by ZNC
Official Full Name: otoconin 90provided by ZNC
Primary source: ZFIN:ZDB-GENE-070912-300
See related: Ensembl:ENSDARG00000001721 AllianceGenome:ZFIN:ZDB-GENE-070912-300
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: otoc1; wu:fb30b04; si:ch211-66b9.2
Summary: Predicted to enable calcium ion binding activity and phospholipase A2 activity. Acts upstream of or within otolith development. Predicted to be located in extracellular region. Is expressed in midbrain hindbrain boundary neural rod; nervous system; otic vesicle; pharyngeal arch 3-7 skeleton; and spinal cord neural rod. Orthologous to human OC90 (otoconin 90). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (42942552..42960352, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (43093134..43110934, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results suggest that Otoc1 may serve to nucleate calcium carbonate mineralization of aragonitic otoliths.(OTOC1 PROTEIN, DANIO RERIO)
Title: Otoc1: a novel otoconin-90 ortholog required for otolith mineralization in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fb30b04.x1 (e-PCR)
- UniSTS:190380

fb30b04.x1 (e-PCR)
- UniSTS:190381

AI437332 (e-PCR)
- UniSTS:206581

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within arachidonic acid secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within otolith development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within otolith development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: otoconin-90

Names: PLA2-like otoconin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080192.2 → NP_001073661.1 otoconin-90 precursor

See identical proteins and their annotated locations for NP_001073661.1

Status: PROVISIONAL

Source sequence(s)

AY826978

UniProtKB/TrEMBL

A0JL26

Related

ENSDARP00000089075.3, ENSDART00000098303.5

Conserved Domains (2) summary

cd04707
Location:739 → 833

otoconin_90; otoconin_90: Phospholipase A2-like domains present in otoconin-90 and otoconin-95, mammal proteins that are principal matrix proteins of calcitic otoconia. Interactions involving otoconin-90 may trigger or constitute key events in otoconia formation. The ...

cl05417
Location:62 → 166

PLA2_like; PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...