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bckdhb branched chain keto acid dehydrogenase E1 subunit beta [ Danio rerio (zebrafish) ]

Gene ID: 569980, updated on 11-Apr-2024

Summary

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Official Symbol
bckdhbprovided by ZNC
Official Full Name
branched chain keto acid dehydrogenase E1 subunit betaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030124-2
See related
Ensembl:ENSDARG00000014676 AllianceGenome:ZFIN:ZDB-GENE-030124-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:158777
Summary
Predicted to enable catalytic activity. Predicted to be involved in branched-chain amino acid catabolic process and response to nutrient. Predicted to be part of mitochondrial alpha-ketoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human BCKDHB (branched chain keto acid dehydrogenase E1 subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See bckdhb in Genome Data Viewer
Location:
chromosome: 16
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (5014287..5105295, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (5147747..5205669, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene inhibitor of Bruton agammaglobulinemia tyrosine kinase Neighboring gene terminal nucleotidyltransferase 5Aa Neighboring gene ttk protein kinase Neighboring gene dynactin 3 (p22)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. Poss KD, et al. Development, 2002 Nov. PMID 12399306
  2. Gene expression analysis of zebrafish melanocytes, iridophores, and retinal pigmented epithelium reveals indicators of biological function and developmental origin. Higdon CW, et al. PLoS One, 2013. PMID 23874447, Free PMC Article
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC158777

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in branched-chain amino acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to nutrient IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of oxoglutarate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
Names
branched chain keto acid dehydrogenase E1, beta polypeptide
NP_001074122.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080653.1 → NP_001074122.1  2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

    See identical proteins and their annotated locations for NP_001074122.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129445
    UniProtKB/TrEMBL
    A1L2C0
    Related
    ENSDARP00000076508.6, ENSDART00000082071.6
    Conserved Domains (3) summary
    cd07036
    Location:74 → 240
    TPP_PYR_E1-PDHc-beta_like; Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins
    PTZ00182
    Location:60 → 389
    PTZ00182; 3-methyl-2-oxobutanate dehydrogenase; Provisional
    pfam02780
    Location:261 → 380
    Transketolase_C; Transketolase, C-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    5014287..5105295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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