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syn1 synapsin I [ Danio rerio (zebrafish) ]

Gene ID: 570672, updated on 25-Apr-2024

Summary

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Official Symbol
syn1provided by ZNC
Official Full Name
synapsin Iprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081105-93
See related
Ensembl:ENSDARG00000060368 AllianceGenome:ZFIN:ZDB-GENE-081105-93
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-90n12.3
Summary
Predicted to enable ATP binding activity and actin binding activity. Predicted to be involved in neurotransmitter secretion. Predicted to be located in Golgi apparatus and synaptic vesicle. Predicted to be active in synaptic vesicle membrane. Is expressed in DEL; nervous system; spinal cord neural tube; and yolk syncytial layer. Human ortholog(s) of this gene implicated in X-linked epilepsy with variable learning disabilities and behavior disorders and non-syndromic X-linked intellectual disability 50. Orthologous to human SYN1 (synapsin I). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See syn1 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (31119302..31148580)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (31109903..31139093)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 20 member 1a Neighboring gene vestigial like 4 like Neighboring gene glycosyltransferase family 92 protein F13G3.3-like Neighboring gene glycosyltransferase family 92 protein F13G3.3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Late onset of Synaptotagmin 2a expression at synapses relevant to social behavior. Goode C, et al. J Comp Neurol, 2021 Jun. PMID 33491202, Free PMC Article
  2. Reversible neuronal and muscular toxicity of caffeine in developing vertebrates. Rodriguez RS, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2014 Jun. PMID 24667760
  3. Identification of an endogenous substrate of zebrafish doublecortin-like protein kinase using a highly active truncation mutant. Shimomura S, et al. J Biochem, 2010 May. PMID 20097902
  4. Relative developmental toxicities of pentachloroanisole and pentachlorophenol in a zebrafish model (Danio rerio). Cheng Y, et al. Ecotoxicol Environ Saf, 2015 Feb. PMID 25463847
  5. Late recruitment of synapsin to nascent synapses is regulated by Cdk5. Easley-Neal C, et al. Cell Rep, 2013 Apr 25. PMID 23602570, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
synapsin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126437.2 → NP_001119909.1  synapsin-1

    Status: PROVISIONAL

    Source sequence(s)
    CR376723
    UniProtKB/TrEMBL
    A0A8N1Z0Y3, B0UXI4
    Related
    ENSDARP00000115298.1, ENSDART00000136578.2
    Conserved Domains (3) summary
    pfam02078
    Location:93 → 190
    Synapsin; Synapsin, N-terminal domain
    pfam10581
    Location:1 → 32
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:192 → 394
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    31119302..31148580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167178.4 → XP_005167235.1  synapsin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BEL9
    Conserved Domains (3) summary
    pfam02078
    Location:93 → 190
    Synapsin; Synapsin, N-terminal domain
    pfam10581
    Location:1 → 32
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:192 → 394
    ATP-grasp_4; ATP-grasp domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394732.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    352928..381699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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