ankha ANKH inorganic pyrophosphate transport regulator a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ankhaprovided by ZNC
Official Full Name: ANKH inorganic pyrophosphate transport regulator aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050913-33
See related: Ensembl:ENSDARG00000071724 AllianceGenome:ZFIN:ZDB-GENE-050913-33
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fj64g09; zgc:110290
Summary: Predicted to enable inorganic diphosphate transmembrane transporter activity and inorganic phosphate transmembrane transporter activity. Predicted to act upstream of or within phosphate ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant craniometaphyseal dysplasia and chondrocalcinosis. Orthologous to human ANKH (ANKH inorganic pyrophosphate transport regulator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (10349147..10394291, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (10208761..10253891, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables inorganic diphosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphate ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ANKH inorganic pyrophosphate transport regulator a; progressive ankylosis-like protein

Names: ankylosis, progressive homolog a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030259.2 → NP_001025430.2 ANKH inorganic pyrophosphate transport regulator a

Status: VALIDATED

Source sequence(s)

CR391965, CT573344

UniProtKB/TrEMBL

A0A8M1N7I5, F1Q528

Related

ENSDARP00000105177.1, ENSDART00000127568.3

Conserved Domains (1) summary

pfam07260
Location:1 → 344

ANKH; Progressive ankylosis protein (ANKH)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

10349147..10394291 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021470216.1 → XP_021325891.1 progressive ankylosis-like protein isoform X1

UniProtKB/TrEMBL

A0A8M9PU68

Conserved Domains (1) summary

pfam07260
Location:1 → 232

ANKH; Progressive ankylosis protein (ANKH)