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Klrc3 killer cell lectin-like receptor subfamily C, member 3 [ Mus musculus (house mouse) ]

Gene ID: 58179, updated on 21-Apr-2024

Summary

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Official Symbol
Klrc3provided by MGI
Official Full Name
killer cell lectin-like receptor subfamily C, member 3provided by MGI
Primary source
MGI:MGI:1929720
See related
Ensembl:ENSMUSG00000033027 AllianceGenome:MGI:1929720
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Klrc2; Nkg2e
Summary
Predicted to enable MHC class I protein complex binding activity; MHC class Ib receptor activity; and protein antigen binding activity. Predicted to be involved in natural killer cell mediated immunity; positive regulation of natural killer cell degranulation; and stimulatory C-type lectin receptor signaling pathway. Located in external side of plasma membrane. Orthologous to several human genes including KLRC1 (killer cell lectin like receptor C1) and KLRC2 (killer cell lectin like receptor C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
6 F3; 6 63.44 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129613226..129620474, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129636263..129643511, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor, subfamily D, member 1 Neighboring gene killer cell lectin-like receptor subfamily K, member 1 Neighboring gene killer cell lectin-like receptor subfamily C, member 2 Neighboring gene killer cell lectin-like receptor subfamily C, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Development and function of CD94-deficient natural killer cells. Orr MT, et al. PLoS One, 2010 Dec 3. PMID 21151939, Free PMC Article
  2. Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing. Ferez M, et al. J Exp Med, 2021 May 3. PMID 33765134, Free PMC Article
  3. Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. Vance RE, et al. J Exp Med, 1999 Dec 20. PMID 10601355, Free PMC Article
  4. Structural basis for NKG2A/CD94 recognition of HLA-E. Kaiser BK, et al. Proc Natl Acad Sci U S A, 2008 May 6. PMID 18448674, Free PMC Article
  5. Bone marrow allograft rejection mediated by a novel murine NK receptor, NKG2I. Koike J, et al. J Exp Med, 2004 Jan 5. PMID 14707119, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of natural killer cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of natural killer cell activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in stimulatory C-type lectin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
killer cell lectin-like receptor subfamily C, member 3
Names
killer cell lectin-like receptor subfamily C, member 2
natural killer cell group 2E cell receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021378.1 → NP_067353.1  killer cell lectin-like receptor subfamily C, member 3

    See identical proteins and their annotated locations for NP_067353.1

    Status: PROVISIONAL

    Source sequence(s)
    AF195779
    Consensus CDS
    CCDS20591.1
    UniProtKB/TrEMBL
    L7N477, Q9QXN7
    Related
    ENSMUSP00000071147.6, ENSMUST00000071149.7
    Conserved Domains (2) summary
    cd03593
    Location:105 → 217
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    PHA03097
    Location:65 → 220
    PHA03097; C-type lectin-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    129613226..129620474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506430.2 → XP_006506493.1  killer cell lectin-like receptor subfamily C, member 3 isoform X1

    UniProtKB/TrEMBL
    A1L3Q6
    Conserved Domains (1) summary
    cd03593
    Location:130 → 242
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
Nucleotide Protein Strain
Heading Accession and Version

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