U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pacsin1b protein kinase C and casein kinase substrate in neurons 1b [ Danio rerio (zebrafish) ]

Gene ID: 619246, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
pacsin1bprovided by ZNC
Official Full Name
protein kinase C and casein kinase substrate in neurons 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050913-35
See related
Ensembl:ENSDARG00000042128 AllianceGenome:ZFIN:ZDB-GENE-050913-35
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fe25d06; pacsin1; wu:fe25d06; zgc:114042
Summary
Predicted to enable phospholipid binding activity. Acts upstream of or within auditory receptor cell stereocilium organization and cilium assembly. Predicted to be located in several cellular components, including cytoplasmic vesicle membrane; cytosol; and ruffle membrane. Predicted to be active in endosome and plasma membrane. Is expressed in nervous system; post-vent region; presumptive neural retina; and trunk. Orthologous to human PACSIN1 (protein kinase C and casein kinase substrate in neurons 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See pacsin1b in Genome Data Viewer
Location:
chromosome: 6
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (54187643..54271535)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (54179535..54263427)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 3b Neighboring gene ribosomal protein S10 Neighboring gene SAM pointed domain containing ETS transcription factor Neighboring gene inflammation and lipid regulator with UBA-like and NBR1-like domains

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Ciliated sensory hair cell formation and function require the F-BAR protein syndapin I and the WH2 domain-based actin nucleator Cobl. Schüler S, et al. J Cell Sci, 2013 Jan 1. PMID 23203810
  2. Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport. Insinna C, et al. Nat Commun, 2019 Jan 25. PMID 30683896, Free PMC Article
  3. Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development. Edeling MA, et al. PLoS One, 2009 Dec 3. PMID 19997509, Free PMC Article
  4. Pacsin2 is required for endocytosis in the zebrafish pronephric tubule. Morgan J, et al. Biol Open, 2022 Jun 15. PMID 35616009, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC114042

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within auditory receptor cell stereocilium organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within plasma membrane tubulation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein kinase C and casein kinase substrate in neurons protein 1
Names
syndapin I
syndapin-1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033728.1 → NP_001028900.1  protein kinase C and casein kinase substrate in neurons protein 1

    See identical proteins and their annotated locations for NP_001028900.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097107
    UniProtKB/Swiss-Prot
    Q4V920
    UniProtKB/TrEMBL
    B2GTA5
    Related
    ENSDARP00000056829.4, ENSDART00000056830.6
    Conserved Domains (2) summary
    cd07680
    Location:18 → 275
    F-BAR_PACSIN1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1)
    cd11998
    Location:389 → 444
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    54187643..54271535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166140.3 → XP_005166197.1  protein kinase C and casein kinase substrate in neurons protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005166197.1

    UniProtKB/Swiss-Prot
    Q4V920
    UniProtKB/TrEMBL
    B2GTA5
    Related
    ENSDARP00000107643.2, ENSDART00000128456.4
    Conserved Domains (2) summary
    cd07680
    Location:18 → 275
    F-BAR_PACSIN1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1)
    cd11998
    Location:389 → 444
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

  2. XM_009302728.3 → XP_009301003.1  protein kinase C and casein kinase substrate in neurons protein 1 isoform X1

    See identical proteins and their annotated locations for XP_009301003.1

    UniProtKB/Swiss-Prot
    Q4V920
    UniProtKB/TrEMBL
    B2GTA5
    Conserved Domains (2) summary
    cd07680
    Location:18 → 275
    F-BAR_PACSIN1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1)
    cd11998
    Location:389 → 444
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V920.1 GenPept UniProtKB/Swiss-Prot:Q4V920

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools